Hello,
I’d like to thank everyone in advance. I have been reading through this website for several months now. I have been on some form of methylation protocol for 2 years with very small improvement. First attempt was oral 800mcg mB12 and 800 mcg mFolate. About 4 months ago I switched to the SMP and worked up to 2 mg hB12, 2mg adoB12, and 12mg mFolate. I found some small improvement on the SMP, but it seemed to stall.
About 3 weeks ago I decided to jump straight into the Active Protocol. I can say for sure that changes are happening, but it’s a mixed bag of good things, bad things, and strange things. Over-methylation, start-up, detox, whatever we want to call it. Something is definitely changing.
The 1st week was a notable improvement in energy and mental clarity. However, this 3rd week symptom pattern has changed to Benzo withdrawal like symptoms. A nervous restlessness, anxiety, depression, jittery, very hard time getting to sleep, mind racing, upset stomach, nausea, low appetite, body aches, tightness in my legs and soles of my feet. It’s a different pattern than my usual CFS symptoms which are mostly dominated by fatigue, body aches, chills, and flu-like symptoms.
By the way, I have two experiences with Benzo withdrawal. One cold turkey followed by reinstating with longer half-life benzo. Then slow 3 month taper supported by high dose 500mg x4 niacinamide to calm withdrawal symptoms a little. I think the benzo withdrawal was the final blow that sent me into full on CFS.
My questions:
1. Does my start-up response seem typical? If not, what needs to be addressed?
2. Active Protocol seems to suggest 50 mg Zinc per day. Should this be offset by copper to maintain a certain ratio? My current intake of Zinc/Copper is 31mg/3.5mg. By the way, I have some random prostate pain.
3. I don’t want to stall start-up or healing if that’s what is really happening; however, are there some technics to help get through the symptoms? i.e. CBT, mindfulness, Epsom Salt Bath, etc.
4. I think I have all Active Protocol Basics covered except Calcium and Vitamin E. Any suggestions on brand, type, dosage? How do these two basics play into Active Protocol process?
5. I have the Jarrow B-Right Complex for my midday dosing, but haven’t tried it. How does this second dosage play into the Active Protocol process?
6. For those Active Protocol veterans, what should I change?
7. Is it possible to take too much methylfolate? Am I just pissing away the extra that my body doesn’t need without any real physical harm? My new nutritionist, who is familiar with methylation, wants me to move up to 15 mg daily. I guess this is in-line with the highest does of Deplin.
AM Regiment:
Vitamin D – 2000 IU
Vitamin C – 500 mg
Emerald Labs Men’s 1 per day
Methyl-life AdoB12 – 3 mg
Jarrow mB12 – 1 mg
Methylfolate – 5 mg
Nature’s Lining – 1 pill
Probiotic – 1 pill
Colostrum – 1.25 g
Fish Oil – 1 pill
Sunflower Lecithin – 7.5 g
Noon Regiment:
Vitamin C – 500 mg
Jarrow mB12 – 1 mg
Methylfolate – 5 mg
Copper – 2 mg
Fish Oil – 1 pill
Dinner Regiment:
Vitamin C – 500 mg
Methylfolate – 1 mg
Nature’s Lining – 1 pill
Zoloft – 12.5 mg
Sunflower Lecithin – 7.5 g
Bedtime Regiment:
Vitamin C – 500 mg
Methyfolate – 1 mg
Mg Glycinate - 200 mg
Mg L-Threonate – 48 mg
Melatonin – 1 mg
Tryptophan – 500 mg
L-Orthinine – 500 mg
Doxylamine succinate (Unisom) – 12.5 mg
I’d like to thank everyone in advance. I have been reading through this website for several months now. I have been on some form of methylation protocol for 2 years with very small improvement. First attempt was oral 800mcg mB12 and 800 mcg mFolate. About 4 months ago I switched to the SMP and worked up to 2 mg hB12, 2mg adoB12, and 12mg mFolate. I found some small improvement on the SMP, but it seemed to stall.
About 3 weeks ago I decided to jump straight into the Active Protocol. I can say for sure that changes are happening, but it’s a mixed bag of good things, bad things, and strange things. Over-methylation, start-up, detox, whatever we want to call it. Something is definitely changing.
The 1st week was a notable improvement in energy and mental clarity. However, this 3rd week symptom pattern has changed to Benzo withdrawal like symptoms. A nervous restlessness, anxiety, depression, jittery, very hard time getting to sleep, mind racing, upset stomach, nausea, low appetite, body aches, tightness in my legs and soles of my feet. It’s a different pattern than my usual CFS symptoms which are mostly dominated by fatigue, body aches, chills, and flu-like symptoms.
By the way, I have two experiences with Benzo withdrawal. One cold turkey followed by reinstating with longer half-life benzo. Then slow 3 month taper supported by high dose 500mg x4 niacinamide to calm withdrawal symptoms a little. I think the benzo withdrawal was the final blow that sent me into full on CFS.
My questions:
1. Does my start-up response seem typical? If not, what needs to be addressed?
2. Active Protocol seems to suggest 50 mg Zinc per day. Should this be offset by copper to maintain a certain ratio? My current intake of Zinc/Copper is 31mg/3.5mg. By the way, I have some random prostate pain.
3. I don’t want to stall start-up or healing if that’s what is really happening; however, are there some technics to help get through the symptoms? i.e. CBT, mindfulness, Epsom Salt Bath, etc.
4. I think I have all Active Protocol Basics covered except Calcium and Vitamin E. Any suggestions on brand, type, dosage? How do these two basics play into Active Protocol process?
5. I have the Jarrow B-Right Complex for my midday dosing, but haven’t tried it. How does this second dosage play into the Active Protocol process?
6. For those Active Protocol veterans, what should I change?
7. Is it possible to take too much methylfolate? Am I just pissing away the extra that my body doesn’t need without any real physical harm? My new nutritionist, who is familiar with methylation, wants me to move up to 15 mg daily. I guess this is in-line with the highest does of Deplin.
AM Regiment:
Vitamin D – 2000 IU
Vitamin C – 500 mg
Emerald Labs Men’s 1 per day
Methyl-life AdoB12 – 3 mg
Jarrow mB12 – 1 mg
Methylfolate – 5 mg
Nature’s Lining – 1 pill
Probiotic – 1 pill
Colostrum – 1.25 g
Fish Oil – 1 pill
Sunflower Lecithin – 7.5 g
Noon Regiment:
Vitamin C – 500 mg
Jarrow mB12 – 1 mg
Methylfolate – 5 mg
Copper – 2 mg
Fish Oil – 1 pill
Dinner Regiment:
Vitamin C – 500 mg
Methylfolate – 1 mg
Nature’s Lining – 1 pill
Zoloft – 12.5 mg
Sunflower Lecithin – 7.5 g
Bedtime Regiment:
Vitamin C – 500 mg
Methyfolate – 1 mg
Mg Glycinate - 200 mg
Mg L-Threonate – 48 mg
Melatonin – 1 mg
Tryptophan – 500 mg
L-Orthinine – 500 mg
Doxylamine succinate (Unisom) – 12.5 mg
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