Fecal microbe transplants help cancer patients respond to immunotherapy and shrink tumors
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The gut microbiome looks like it has powerful effects outside of the gut.
This is a quote from the article.......
This is a quote from the article.......
Yes lot's of studies indicate bacteria in your gut have effects on all kinds of things outside of your gut.
Always a little leery about this area of research being overly hyped though.
Most is centered around how it affects your health but none how our immune systems respond to it and how that might be just as important of a dynamic to be considered.
Or in other words if someone has depression and you have associated the lack of one thing or the presence of another for the condition it might not be as simple as adding or subtracting that particular species.
The way an individuals immune system responds to it might in a large degree affect the outcome also.
Maybe there are some kinds of drugs that could regulate how the immune system responds to intestinal flora.
Maybe there are certain types of flora in our guts (or absence of said flora) that have detrimental effects on our immune system and if they could first be addressed a lot of the other conditions would not be much of an issue or maybe be sorted out on their own without a need for an intervention.
Keep meaning to read more posts here about people who tried fecal transplants to see what their experiences have been like.
Thing that scares me is it would seem just as easy to have a bad outcome depending on what the donar is exposing you to.
Not sure weather they are standardized for people with any conditions other than c-difficile.
I just don't have the time to do research or read posts here. Wondering what recent studies on the efficacy rate of fecal transplantation are saying.
Apparently there still needs to be research in this area. And clinitions still don't use it as a first line of defence against c-difficile.
https://www.hopkinsmedicine.org/gas...advanced_endoscopy/fecal_transplantation.html
Always a little leery about this area of research being overly hyped though.
Most is centered around how it affects your health but none how our immune systems respond to it and how that might be just as important of a dynamic to be considered.
Or in other words if someone has depression and you have associated the lack of one thing or the presence of another for the condition it might not be as simple as adding or subtracting that particular species.
The way an individuals immune system responds to it might in a large degree affect the outcome also.
Maybe there are some kinds of drugs that could regulate how the immune system responds to intestinal flora.
Maybe there are certain types of flora in our guts (or absence of said flora) that have detrimental effects on our immune system and if they could first be addressed a lot of the other conditions would not be much of an issue or maybe be sorted out on their own without a need for an intervention.
Keep meaning to read more posts here about people who tried fecal transplants to see what their experiences have been like.
Thing that scares me is it would seem just as easy to have a bad outcome depending on what the donar is exposing you to.
Not sure weather they are standardized for people with any conditions other than c-difficile.
I just don't have the time to do research or read posts here. Wondering what recent studies on the efficacy rate of fecal transplantation are saying.
Apparently there still needs to be research in this area. And clinitions still don't use it as a first line of defence against c-difficile.
https://www.hopkinsmedicine.org/gas...advanced_endoscopy/fecal_transplantation.html
I don't have much time to read and research anymore either. I did just read a little bit about the efficacy of FMT in Clostridium Difficile. The research paper was published last April 2020. It said there hasn't been enough studies done to accurately know how well FMT works in CD.
While I do agree that there's some hype about the gut microbiome causing or contributing to many diseases. I think there is a lot of evidence that much of it is true.
I've read a study of FMT that was effective in treating Autism and one for ME/CFS done by Thomas Borody. The Borody study found a 58% success rate at putting ME/CFS into remission, after a 15-20 year follow up.
Both the study done on Autism and ME/CFS were done differently than most FMT. Borody cultured I think it was 13 healthy bacteria from the gut and used those to treat the ME/CFS patients. It is actually called "bacteriotherapy" not FMT but it's the same basic idea.
The successful study done on Autism first used a very powerful antibiotic ( I think it was Vancomycin) to wipe out any bacterial imbalances in the gut. Then used FMT from several donors, I think 10 for each patient, over several weeks.
This is the Borody study-
Reference
This quote is from the Autism study-
Reference
My question is, if they could make FMT 100% effective in re-balancing the gut microbiome, how much better would these study results be???
While I do agree that there's some hype about the gut microbiome causing or contributing to many diseases. I think there is a lot of evidence that much of it is true.
I've read a study of FMT that was effective in treating Autism and one for ME/CFS done by Thomas Borody. The Borody study found a 58% success rate at putting ME/CFS into remission, after a 15-20 year follow up.
Both the study done on Autism and ME/CFS were done differently than most FMT. Borody cultured I think it was 13 healthy bacteria from the gut and used those to treat the ME/CFS patients. It is actually called "bacteriotherapy" not FMT but it's the same basic idea.
The successful study done on Autism first used a very powerful antibiotic ( I think it was Vancomycin) to wipe out any bacterial imbalances in the gut. Then used FMT from several donors, I think 10 for each patient, over several weeks.
This is the Borody study-
Reference
This quote is from the Autism study-
Reference
My question is, if they could make FMT 100% effective in re-balancing the gut microbiome, how much better would these study results be???
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You would think researchers and dr's that treat CFS would be all over this with results that impressive? Are there any posts on' this form with people having that level of success?
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Thanks for sharing this article. As Craysing is an immunotherapy it made me consider the importance of healthy gut flora on apoptosis.
I agree. I wonder how many Dr's or researchers know about it.
There is one guy here that used his 5 year old daughters stool. She had never taken any antibiotics in her life and was very healthy. He developed ME/CFS after getting MRSA and was given MASSIVE amounts of antibiotics, much of which were given intravenously .
This guy wiped out his gut bacteria with antibiotics, followed by the FMT's. He also used a centrifuge and used multiple layers of digestion resistant capsules to prepare the FMT's.
It really looks like HOW the FMT is done, is one of the biggest determining factors in weather it's successful or not.
This is a quote from a thread he started-
His last post was January 2019. I am assuming he is still 100%. Last I knew he was doing martial arts and all kinds of cardio with no problem. He has a blog somewhere detailing his experience but I can't find it!
There is one guy here that used his 5 year old daughters stool. She had never taken any antibiotics in her life and was very healthy. He developed ME/CFS after getting MRSA and was given MASSIVE amounts of antibiotics, much of which were given intravenously .
This guy wiped out his gut bacteria with antibiotics, followed by the FMT's. He also used a centrifuge and used multiple layers of digestion resistant capsules to prepare the FMT's.
It really looks like HOW the FMT is done, is one of the biggest determining factors in weather it's successful or not.
This is a quote from a thread he started-
His last post was January 2019. I am assuming he is still 100%. Last I knew he was doing martial arts and all kinds of cardio with no problem. He has a blog somewhere detailing his experience but I can't find it!
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Probably very few. Nutrition and supplementation gets very few hours of medical education and most MDs only learn it on the side out of desperation if they have a personal problem that is not responding to medicine. This is so bad that the authorities are not even telling the public that following a low inflammation, low glyfosate diet dramatically lowers the severity and mortality of coronavirus-19 infection. This mainly protects the food and pharmaceutical industry (Bayer who makes glyfosate and glyfosate resistant seed).
My favorite medical author on nutrition is the neurologist David Perlmutter MD.
My favorite medical author on nutrition is the neurologist David Perlmutter MD.
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I've dreamed of an outcome like that for 23 years. Surely anyone who is anybody knows about this! Why aren't they doing more trials and studies?
I've had that same dream for a long time. I've had ME/CFS for 43 years.
Studies are being done but not a lot from what I've seen in my research. I think a big part of the problem is that there are too many theories about what causes ME/CFS. So the amount of research going into FMT is a lot less than it should be.
Here is a link to another study done in ME/CFS with very impressive outcomes. A high percentage of people with ME/CFS had between a 75-95% improvement in the symptoms.
As they better perfect FMT, that percentage will go even higher.
Studies are being done but not a lot from what I've seen in my research. I think a big part of the problem is that there are too many theories about what causes ME/CFS. So the amount of research going into FMT is a lot less than it should be.
Here is a link to another study done in ME/CFS with very impressive outcomes. A high percentage of people with ME/CFS had between a 75-95% improvement in the symptoms.
As they better perfect FMT, that percentage will go even higher.
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I've had that same dream for a long time. I've had ME/CFS for 43 years..
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Like to see more people doing it and getting better with the treatment. Than I would definitely look into it.
I think if they really new the true level of suffering from this illness and that it's not psychological, that would be different. At least I hope it would be. I feel fortunate to some degree, that I am functioning at a level 6.
I think I would try it if I had a good donor and could afford to have their gut microbiome tested for pathogens etc. At this point I don't have either.
I think I would try it if I had a good donor and could afford to have their gut microbiome tested for pathogens etc. At this point I don't have either.
When I was inside a moldy house I was for all intent's and purposes bed bound. I could manage my shopping feeding myself some household cleaning but not much more than that. And I had to push myself (pull myself up by the straps) which meant crashes.
When I moved to my back yard I got a lot more of my health back. Been at about that level since except when I moved back into houses which always seem to make me worse even when there is no visible mold.
My dad's place in North Carolina put me all the way back to bed bound. Had to crawl out on my hands and knees and sleep in a tent for a week before I could get some sense of normalcy back.
I am 61 so I figure age is affecting me at this point to some degree. But if I conserve energy and take a 1 or two hour nap after lunch I can run the rest of the day doing some light chores and spending time on my computer. If I skip the nap which isn't optional most the time, I won't make it till 11pm. I'll fall asleep at 8 or 9pm.
High cognitive tasks that require problem solving cause stress and are very difficult. I have taxes coming up. At first it is hard and daunting. Gotten much easier and less daunting since I can get all my records online and turbo tax makes all the calculations..
I still suspect an environmental component. My housing is alternative. Metal building I sheathed the inside with foam panels and suspect the fire retardants and styrene are causing me problems. I never make any real progress in my life. I am just treading water. I have a large chore, have to fix a roof. Been putting it off. Will be a ensuing crash after I get it done.
I watch my neighbor who is close to 80 starting a little over ten years ago build a palace from scratch. Dig ditches, put in irrigation system, fix things. There was a time when I could do that!
When I go into town 55 miles away it is an all day event. Many times I am a vegetable the next day but don't crash since driving isn't that physically demanding, shopping isn't that much more than light household chores. Still next day will likely be a recovery day.
I suspect my level around the same level of functioning as a 6?
If it were any worse than it is I don't know how I could cope!
When I moved to my back yard I got a lot more of my health back. Been at about that level since except when I moved back into houses which always seem to make me worse even when there is no visible mold.
My dad's place in North Carolina put me all the way back to bed bound. Had to crawl out on my hands and knees and sleep in a tent for a week before I could get some sense of normalcy back.
I am 61 so I figure age is affecting me at this point to some degree. But if I conserve energy and take a 1 or two hour nap after lunch I can run the rest of the day doing some light chores and spending time on my computer. If I skip the nap which isn't optional most the time, I won't make it till 11pm. I'll fall asleep at 8 or 9pm.
High cognitive tasks that require problem solving cause stress and are very difficult. I have taxes coming up. At first it is hard and daunting. Gotten much easier and less daunting since I can get all my records online and turbo tax makes all the calculations..
I still suspect an environmental component. My housing is alternative. Metal building I sheathed the inside with foam panels and suspect the fire retardants and styrene are causing me problems. I never make any real progress in my life. I am just treading water. I have a large chore, have to fix a roof. Been putting it off. Will be a ensuing crash after I get it done.
I watch my neighbor who is close to 80 starting a little over ten years ago build a palace from scratch. Dig ditches, put in irrigation system, fix things. There was a time when I could do that!
When I go into town 55 miles away it is an all day event. Many times I am a vegetable the next day but don't crash since driving isn't that physically demanding, shopping isn't that much more than light household chores. Still next day will likely be a recovery day.
I suspect my level around the same level of functioning as a 6?
If it were any worse than it is I don't know how I could cope!