So, maybe the question to ask is what do infections and high intensity physical exercise have in common? We already know that B12 is involved in the disease process. B12 is often called the energy vitamin because it helps fat and protein to metabolize in the body. It also plays a major role in the conversion of carbohydrates to glucose-your body's source of fuel. In addition, B12 enables your body to convert fatty acids into energy. It is also a promoter of normal immune function.
Intense physical exercise would deplete your body of B12. High intensity physical exercise also raises homocysteine. B12 is necessary to recycle homocysteine. So, it does impact the methylation cycle.
So, where does B12 come from? It is made by organisms in the soil. An animal that is pastured ingests B12 and we get B12 by eating proteins that come from animals that are pastured, such as eggs, meat, fish , dairy. A Tufts University study found that 40% of Americans were deficient enough in B12 to cause neurological damage. The study also found that we were consuming these proteins, but were not properly metabolizing B12. So, the problem lies in the metabolism. Is there something involved in the metabolism of B12 that would also directly impact immune function? The answer to this question could explain a great deal. It could also explain the biological findings in the disease process, such as low B12 and iron. An immune system "gone haywire" does not explain the biological findings in autoimmune disease, such as low dopamine in fibromyalgia or low acylcarnitine in the blood or muscles of people with CFS/FMS.