@Martin aka paused||M.E. - Just going to pipe in here that I too am Mannose-Binding Lectin deficient. I had my genetics tested and saw that I carried the mutation, so I asked my doctor if I could get tested. I tested at a 3. This is the language in my lab reportEveryone seems to blow this mutation off because it is so common. But I am curious if the values within the ME/CFS community are frequently as low and Martin and my readings. We are both essentially completely deficient.
Clinical studies have used 50 or 100 ng/mL to define severe MBL deficiency. MBL is also known to activate the classical complement pathway through its binding to serine proteases MASP-2 and MASP-1. MBL deficiency has been associated with recurrent infections in children 6 months to 17 months of age, during the time when the adaptive immune system (IgG production) is not fully mature.