“Emerging Options for Autoimmune ME/CFS”: Scheibenbogen at the 2021 IACFS/ME Conference Sep 16, 2021


Senior Member

In her “Emerging options for Autoimmune ME/CFS” presentation, Scheibenbogen laid out the case for an autoimmune cause of ME/CFS in at least a subset of patients. There’s the infectious trigger (often EBV – a stellar autoimmune disease trigger), evidence of increased family histories of autoimmunity, and study results.

Scheibenbogen’s been focused on B-adrenergic, M-acetylcholine, ATI and ETA receptor autoantibodies. She hastened to note autoantibodies, including the ones she’s looking at, can have positive effects. These are natural autoantibodies – they’re found in everyone, healthy and non-healthy alike – and at the right levels they’re helpful, but in some diseases, they’ve been shown to produce problems.

A recent study assessing endothelial functioning suggested blood vessel problems may be common. Endothelial functioning refers to the ability of the endothelial cells to vasodilate, or enlarge, the blood vessels. Inadequate endothelial functioning potentially means reduced delivery of the blood to the muscles, brain, etc. The study found that was reduced in about half of ME/CFS patients, and people with worsened endothelial function had more severe disease.

They certainly seem handmade for ME/CFS. They can vasoconstrict the blood vessels, causing the release of vasodilators and pain-enhancing subjects such as bradykinin, and ultimately reduced blood flows to the muscles, the brain, as well as leakage from the capillaries and low blood volume.

Read more at: https://www.healthrising.org/blog/2...tions-chronic-fatigue-syndrome-scheibenbogen/