The big multi-year, multi-million dollar RO1 grant titled “Molecular and Single Cell Immunology of ME/CFS” lasts for five years and pays out a cool $745,000 this year.
...In this study Mark Davis will look at an array of T-cells to determine the breadth and extent of the T-cell activation in ME/CFS. He’ll pair that with new technology developed by Ron Davis which gives researchers a better handle on the genes used to capture those pathogenic antigens.
By the time the study is done we could know if ME/CFS is an autoimmune disease or is caused by a pathogen (or both!), Plus we could know what specifically has tweaked our immune systems. Plus Ron Davis, in a section of the grant, which shows his predilection for long term thinking, envisions the study as the opportunity to build a new (and precise) molecular framework for understanding, diagnosing and treating ME/CFS.