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When Dr. Chia refers to enteroviral infection, does anyone know which one he means? When I researched enteroviruses, they are numerous kinds. I was wondering if anyone knows. Thanks very much.
http://enterovirusfoundation.org/associations.shtmlChronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a complex and debilitating illness that affects the brain and multiple body systems. Symptoms include widespread muscle and joint pain, cognitive difficulties, chronic, often severe mental and physical exhaustion and other characteristic symptoms in a previously healthy and active person.
A recent study found VP1, RNA and non-cytopathic viruses in the stomach biopsy specimens of CFS/ME patients with chronic abdominal complaints. A significant subset of CFS/ME patients may have a chronic, disseminated, non-cytolytic form of enteroviral infection, which could be diagnosed by stomach biopsy.
For more information:
Chia, JKS, Chia, AY;(2008), "Chronic fatigue syndrome is associated with chronic enteroviral infection of the stomach," Journal of Clinical Pathology 2008;61:43-48.
I think he's interested in any non-polio enterovirus in ME/CFS, but his 2005 study mentions finding six coxsackieviruses and five echoviruses. He also mentions that "Three patients with strongly positive enteroviral RNA in their PBMC had no detectable neutralising antibody to the 11 enteroviruses tested, which suggested that infections could be caused by the other echoviruses or enteroviruses not identified by commercially available neutralising antibody tests."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770761/?tool=pubmed