Donations for a trial using BC 007 specifically for me/cfs

Marylib

Senior Member
Messages
831
Likes
820
I'm totally confused who is advocating for what because the Covid vaccine injured people are looking for it too. It makes sense because something went way wrong with that vaccine for some people.
 

Shanti1

Senior Member
Messages
328
Likes
1,167
I think it only targets certain antibodies, namely the GPCR autoantibodies, specifically the beta-1 adrenergic and the alpha-1 adrenergic receptor. Here is a quote on this from another thread:

https://forums.phoenixrising.me/thr...ases-applicable-to-me-cfs.84695/#post-2352589
Wirth and Sheibenorgen hypothesise in their new paper that beta 2-adrenergic receptor dysfunction is of critical importance in the pathophysiology of ME/CFS, in causing vascular dysregulation.

While BC 007 has been found to have effect in Long Covid via eliminating functional pathogenic autoantibodies directed against the beta-1 adrenoceptor, Berlin Cures has also assessed it for neutralising GPCR autoantibodies against all of alpha-1 adrenergic receptor (α(1)-AR AAB), beta-1 adrenergic receptor (ß(1)-AR AAB), beta-2 adrenergic receptor (ß(2)-AR AAB) and endothelin-A-receptor (ETA AAB) and found BC 007 to be effective for all of these.
https://www.prnewswire.co.uk/news-r...of-bc-007-for-the-treatment-of-691428881.html
https://clinicaltrials.gov/ct2/show/NCT02955420

It has been supported by others researching dementia that BC 007 can neutralise GPCR autoantibodies against beta 1 and 2 adrenergic receptors in that condition.
https://pubmed.ncbi.nlm.nih.gov/29538413/

Wirth and Sheibenorgen hypothesise in their new paper (Pathophysiology of skeletal muscle disturbances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) that beta 2-adrenergic receptor dysfunction is of critical importance in the pathophysiology of ME/CFS, in causing vascular dysregulation, so BC 007 may have some potential for ME/CFS also.
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02833-2
My question is, it seems that only a subset of ME/CFS patients are positive for these autoantibodies (https://pubmed.ncbi.nlm.nih.gov/26399744/), does this mean this medication would only be helpful for those individuals?
 

bensmith

Senior Member
Messages
1,429
Likes
3,051
@shanti , i’d think so yes. And even some
Of the positives would likely fail treatment too, i’d guss.