I take them hours apart too. I take one metafolin in the morning, followed by a mb12 sublingual. Here I consider the effectiveness issue.Later, in the afternoon, I take another mb12 sublingual and after finishing the mb12, I take the adb12. So my first mb12 dose is after the metafolin(I think its effective this way), and the next mb12 & adb12 dose in the afternoon is well,hours apart. I would also like to know more about the effectiveness.