Does anybody inject LDN?

Johannes

Senior Member
Messages
339
If you do, do you inject subcutaneously or intramuscularly? What would be the dosage?
 

Hip

Senior Member
Messages
18,116
Why would you want to inject LDN?

Naltrexone has a very high oral bioavailability of 96%, so it is almost completely absorbed into the bloodstream.
 
Last edited:

Johannes

Senior Member
Messages
339
Because I have so bad chemical sensitivity that can't tolerate any medicines or supplements. If I put any of them into my mouth, not to talk about my sctomach or bowel, I will have bad bowel inflammation and fever in a week. The same happends if I use transdermal drugs. My doctor says I will have cancer if I continue using oral medicines or supplements, due to inflammation and lesions in my bowel.
 

pamojja

Senior Member
Messages
2,487
Location
Austria
The same happends if I use transdermal drugs.

If even transdermal drugs cause bowel inflammation and fever in a week, injections wont fare any better.

However transdermal drugs - usually in high doses for their effects - might be a completely different animal, than for example transdermal supplements. Like Mg, B12, or even LDN (because of its very low dose compared to standard drug doses).
 

Johannes

Senior Member
Messages
339
You may be right but it seems to vary according to what I inject. I get no symptoms if I inject pure methyl cobalamin without precervatives or anything other than this vitamin and pH adjustment. Pure Adenosyl cobalamin solution doesn't cause any symptoms. The same goes with 5-MTHF injections, vitamin D3 and seasonal influenza injections. But hepatitis A + B injection and Lyme disease injections cause bowel inflammation. So I have to try them one by one. It is worth trying LDN injections just encase I wouldn't get symptoms...although, I doubt I can inject LDN either. :(
 

Hip

Senior Member
Messages
18,116
Because I have so bad chemical sensitivity that can't tolerate any medicines or supplements. If I put any of them into my mouth, not to talk about my sctomach or bowel, I will have bad bowel inflammation and fever in a week.

Sorry to hear you have such troubles. Has you doctor considered an MCAS diagnosis for you? That's a different thing to multiple chemical sensitivity (MCS), but has similar symptoms. MCAS is treatable to an extent.

One thing you could try is transdermal naltrexone, which I think in theory would be absorbed. The molecular weight of naltrexone is 341 daltons, and molecules below around 500 daltons are small enough to be absorbed through the skin.

You could crush down a tablet of naltrexone into fine powder and apply the appropriate dose as a powder on your skin. Or if like some people you dissolve your naltrexone in water and apply a dose by a pipette, you could place that on your skin.
 

Johannes

Senior Member
Messages
339
Thanks Hip for that valuable information about LDNs molecular weight. I used to study chemistry and have a degree of laboratory technician but CFS has taken my memory and I don't remember most of what I learned anymore. I have to find someone who would give me a few LDN tablets and try it.

One doctor said I might have MCAS and what I red about it, my symptoms are pretty close to it. But I can't tolerate H1 and H2 blockers or other MCAS medicines and my MCAS symptoms disappear with lots of vitamin D3. My vit D level is approximately 201nmol/l = 80 ng/ml. The only MCAS symptom I now have is sensitivity to many foods, drugs and supplements. And terrible muscle weakness, some cognitive broblems, depression and bad fatigue. About a dozen of different kinds of MCAS symptoms disappear when my vit D level rises high enough. But after having enough sunshine, I get a a lot better. Even my bowel symptoms start to disappear. That is why I am now starting to test red light and near-infrared light therapy. There are only one or a few doctors that have even heard of MCAS i Finland, where I live. It is not a diagnosis in Finland at all.
 

kangaSue

Senior Member
Messages
1,894
Location
Brisbane, Australia
Because I have so bad chemical sensitivity that can't tolerate any medicines or supplements. If I put any of them into my mouth, not to talk about my sctomach or bowel, I will have bad bowel inflammation and fever in a week. The same happends if I use transdermal drugs. My doctor says I will have cancer if I continue using oral medicines or supplements, due to inflammation and lesions in my bowel.
Do you have an inflammatory bowel disease to cause your bowel lesions? If not, have you had a CT angiogram or Doppler ultrasound done of your mesentery arteries to check out the bowel blood flow situation?

I have a deficiency in this area, diagnosed as non-occlusive Chronic Mesenteric Ischemia, and have gastroparesis from it, as well as significant food, medication and supplement intolerances. The bowel ischemia was diagnosed from the presence of a bowel lesion found in the transverse colon and as there was no evidence found of any artery blockage, determined to be non-occlusive ischemia "of unknown etiolgy".

I can't tolerate oral or transdermal Vit D either. I have to get it from short bursts of sun exposure but that also causes me abdominal pain because of having a very poor sweat response, because of having Autonomic Neuropathy (and as it happens, autonomic dysfunction can also be a cause of non-occlusive Chronic Mesenteric Ischemia).

I have tried megadose intramuscular injections of Vit D (600,000IU) which only caused mild abdominal discomfort for a day or so but my system couldn't hold onto it or convert it due to being on a low fat diet for gastroparesis and having little body fat left due to limited calorie intake.
https://www.ncbi.nlm.nih.gov/pubmed/15992330

Regarding your LDN question, I have a problem with gelatin and vegecaps due to the sensitivities issues and found that taking LDN was more tolerable with just dissolving the contents of the capsules in water and swallowing it. Still run into problems with it after about a month though and had to stop it because of worsening abdominal pain in taking it. To start with, LDN was helping a lot for abdominal pain.
 

Johannes

Senior Member
Messages
339
@kangaSue I was diagnosed with crohns disease at first. I had all the symptoms and lessions, pain in my bowel and high calprotectine. I was a typical case, with my severe vitamin D deficiency. I had colonoscopy, my small intestine and stomach was checked too. I swallowed a capsule camera with which they videoed my whole bowel. Later they did MRI for whole bowel.

But as soon as they started to inject vitamin D 2500 micrograms every three months, my symptoms started become milder. I asked to have bigger dosage, so they gave me 2500 micrograms every second month and my bowel healed: no lesions, no vitamin D deficiency, no pain in the bowel and normal Calprotectine and also normal blood tests. So, I don't think I have chrohns disease but my doctor just says my crohns disease is dormant. I haven't had these symptoms for almost six years now unless I eat certain foods, medicines or supplements.

I am on a Failsafe elimination diet developed by Royal Prince Alfred Hospital at Sydney, avoiding salicylates, amines, glutamate and food additives. That elimination diet saved me from bowel inflammation.

It sounds weird that one would need fat from diet when one is injected with vitamin D. I mean, one needs fat to abrorb vitamin D from food (to carry it through the bowel) but injections don't have to absorb as vitamin D in them is already in a soluble form, readily be used by the liver. One doesn't need fat every day even when using oral vitamin D. But I quess it is possible.

My kidneys don't convert vitamin 3D to active form efficiently, propably due to mitochondio myopathy I have.
 
Last edited:

kangaSue

Senior Member
Messages
1,894
Location
Brisbane, Australia
But as soon as they started to inject vitamin D 2500 micrograms every three months, my symptoms started become milder. I asked to have bigger dosage, so they gave me 2500 micrograms every second month and my bowel healed: no lesions, no vitamin D deficiency, no pain in the bowel and normal Calprotectine and also normal blood tests. So, I don't think I have chrohns disease but my doctor just says my crohns disease is dormant. I haven't had these symptoms for almost six years now unless I eat certain foods, medicines or supplements.
Well in a roundabout way, I guess vitamin D can be protective of the intestinal mucosa when it's helping to correct a gut bacterial imbalance;
https://www.ncbi.nlm.nih.gov/pubmed/27515213 Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a "pro-inflammatory" state associated with atherosclerosis and autoimmunity.
It sounds weird that one would need fat from diet when one is injected with vitamin D. I mean, one needs fat to abrorb vitamin D from food (to carry it through the bowel) but injections don't have to absorb as vitamin D in them is already in a soluble form, readily be used by the liver. One doesn't need fat every day even when using oral vitamin D. But I quess it is possible.
I have to assume that my Endocrinologist knows what she's talking about when she says a lack of body and dietary fat is part of the issue with vitamin D and it being a fat soluble vitamin. I do have a renal problem too but it's with the return blood flow (Nutcracker Syndrome - occluded left renal vein) and the actual kidney function itself is good. Something I need to delve into a bit more now though I think.
 
Back