At 24 Total Votes right now...
RESULTS: 14 out of 17 (82.4%) have Active EBV infection
(with 7 undetermined)
I will explain...
btw, I was really hoping for more results before I submitted this post. But, it's good enough.
I set this Poll up because after speaking w/ so many of you on this forum, it became very clear people did not know if they had an active EBV infection. In fact, many were sure they did NOT in fact have an active EBV infection. This is because either the patient or the doctor could not accurately interpret the test results.
I purposefully put choices in this poll that are actually incorrect answers
. I wanted to see others' interpretations of their own results. I wanted to show others how important it is to be able to correctly interpret EBV test results.
Do you have an active EBV infection?
Red w/ strike-through are incorrect answers.
- Yes - I have high VCA IgM titers
- Yes - I have high Early Antigen (EA) IgG titers
- Yes - But my VCA IgM and Early Antigen (EA) IgG titers are normal
- No - VCA IgM and Early Antigen (EA) IgG titers are normal
- No - VCA IgM is normal and Early Antigen (EA) IgG titers are high
- No - VCA IgM is normal and I haven't tested for Early Antigen (EA) IgG
- I haven't had any EBV testing done.
No one has yet to mark this one, so that's good. It's incorrect because if you have normal results for IgM AND Early Antigen (EA), then the answer would be NO, you do NOT have an active infection.
If you have positive (or high) titer results for Early Antigen (EA), you almost always
have an active EBV infection, even if IgM is negative/normal.
This is only HALF incorrect. It COULD actually be correct, but there's not enough information provided to make that determination. If you haven't had Early Antigen (EA) tested, then you don't know whether or not you have an active infection. So, this answer could in fact be "No", but w/out testing EA, there's no way to know whether you do or do not have an active infection.
So, here are the correct EBV lab interpretations to know:
VCA IgM Positive (Initial Infection, ACTIVE)
This means you have an active EBV infection and that this infection is not a reactivation of the virus, but the initial primary infection. And your body never subdued the initial virus.
Early Antigen (EA) IgG Positive (Re-Activated Infection, ACTIVE)
This means you have an active EBV infection. Now, it gets tricky here because people have been taught that if IgM is negative/normal, then you DON'T have an active EBV infection. However, if you have negative IgM and positive Early Antigen (EA), this means you have a RE-activation
of the virus. So, you have an active EBV infection, it's just not from when you first got the infection, but rather it was dormant/latent, and got re-activated. This is where the confusion occurs.
*The whole idea here is to NOT confuse people. But, it should be noted that you can have positive EA IgG and VCA IgM. But IgM positive still means it's the initial infection.
Early Antigen (EA) IgG and VCA IgM matter. Positive for either means EBV is active.
VCA IgG and Nuclear Antigen IgG don't matter much at all.
That said, though the sample is small thus far .....
82.4% of us have active EBV infection
* Here's the caveat that I believe many want to know about...
Studies have been done showing positive Early Antigen (EA) titers in BOTH ME/CFS patients AND healthy subjects.
So, WHY, in some studies do healthy controls have elevated (EA) titers?
The answer is complex. But to this date, the main theory is that healthy individuals CAN have an active EBV infection. And that they don't get CFS symptoms because their EBV infection has not replicated in certain genes.
This hypothesis was given way back in 2010
, that healthy individuals testing positive for Early Antigen (EA), have EBV replication in just the first 30 early EBV genes
, which may not be enough to disrupt cellular metabolism causing CFS symptoms.
Whereas ME/CFS patients w/ the same positive testing for Early Antigen (EA) have EBV replication to middle and/or late EBV genes
beyond the 50th linear gene, necessary for CFS illness.
That hypothesis was from 2010. Now here's something more people are familiar w/ as this was from an important 2019 study.
EBV-induced EBI2 gene is upregulated in CFS patients.
So, this could suggest that EBI2
could be the culprit. And if an active EBV replication in Gene 2 (EBI2) is present, then CFS symptoms occur.
The point is this. Healthy individuals can have an active infection and not present any fatigue symptoms at all. Whereas someone w/ chronic fatigue can have the same test results as the healthy individual. The main difference being the gene expressions of that particular viral infection.