I started with a minimalist approach (MB12 and Mfolate) but have begun to supplement some things like B1/B complex and potassium/electrolytes. Those things have been of benefit, but they've caused other issues, most notably depression and/or anxiety/nervousness. I removed niacin from the equation in case it was soaking up too much methyl, but I'm still getting the issues. I seem to get improvement by upping my B12 and/or folate beyond what I'd been doing. Is that typical? I.e., do adding in Bs and/or electrolytes open up pathways that cause the B12 and folate to be used up more quickly, hence you need to supply more of them (a blessing since the goal is to be upping those)?