These are my take away messages, and not a direct transcript in any way.
IL-15 restores NK cell cytotoxicity in vitro.
I started talking about homeostasis and reset decades ago.
They need modelling because they are not just looking at patterns, they need to predict proximal causation and then predict if an intervention, such as a combination of drugs, will work. This happens in a highly dynamic system. This is much more classical modelling, though very advanced modelling, than a typical AI analysis.
Some patients were already over their anaerobic threshold before starting exercise and so were disqualified as its too risky to test them.
First pathways disrupted from exercise in WBCs are immune. The second wave are metabolic, including oxidative stress, sensory and blood pressure regulation.
Teasing out the pattern of events after exercise might lead to major breakthroughs understanding PEM.
GWI and CFS are clinically similar, but there are some big differences in the biochemistry. With GWI there is a massive increase in molecular pathways, in CFS there is a massive decrease. To my way of thinking that makes CFS and GWI almost opposites.
This is about chaos theory to a large extent. I was discussing this in the 90s. The early models I was working with were about homeostasis but based on hormones and hypoxia. These ideas were not advanced very far, and are nothing like the level of complexity we see now.
A human clinical trial for resetting homeostasis in GWI is due to start soon, based in part on a successful animal model. Funding has been found to do this in ME/CFS. The principle is to inhibit tumour necrosis factor alpha, followed by inhibiting the glucocorticoid response, in a one two fashion. How they create sick animals is give them a toxin, then cortisol, then more toxin, then more cortisol, and they never recover. That is they do not recover until they have their homeostatitic set points reset. That is lower neuroinflammation then lower the cortisol response.
The proposed trigger is anything that induce neuroinflammation followed by elevated cortisol. This applies to the initial trigger but also relapses.