Direct Evidence that Gut Microbes (Microbiome) Can Interfere with the Delivery of a Drug Within the Human Body

Wally

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https://www.sciencedaily.com/releases/2019/06/190613143629.htm
Gut microbes eat our medication

Date: June 13, 2019
Source: Harvard University
Summary: Researchers have discovered one of the first concrete examples of how the microbiome can interfere with a drug's intended path through the body. Focusing on levodopa (L-dopa), the primary treatment for Parkinson's disease, they identified which bacteria out of the trillions of species is responsible for degrading the drug and how to stop this microbial interference.
Scientists at “. . .University of California San Francisco, describe one of the first concrete examples of how the microbiome can interfere with a drug's intended path through the body. Focusing on levodopa (L-dopa), the primary treatment for Parkinson's disease, they identified which bacteria are responsible for degrading the drug and how to stop this microbial interference.”

Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. Science, 2019; 364 (6445): eaau6323 DOI: 10.1126/science.aau6323