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Deplin for depression

Messages
15
Hi has anybody tried Deplin ? . I have read some encouraging stuff on the internet with regards to it helping with depression or helping your antidepressant work better. I would be interested if anyone has some feedback with regard to this. I would much rather be taking something that may be addressing a folate problem than taking too much psych meds. Thanks.
 

Rand56

Senior Member
Messages
675
Location
Myrtle Beach, SC
Hi has anybody tried Deplin ? . I have read some encouraging stuff on the internet with regards to it helping with depression or helping your antidepressant work better. I would be interested if anyone has some feedback with regard to this. I would much rather be taking something that may be addressing a folate problem than taking too much psych meds. Thanks.

hi kiteman

I tried the larger doses of l-methylfolate for my depression. I tried the 7.5mg first with no response and even upped it to 15mg. I had no response to that dose either. I felt I gave it ample time. Worth a shot to try if you can handle even smaller doses of it. Just because it didn't work for me doesn't mean it won't work for you or others. From what I understand, if it does work for you it's still not a quick fix, I'd give it atleast a month. I've been a non-responder before with many AD's so take that for what it's worth.
 

nanonug

Senior Member
Messages
1,709
Location
Virginia, USA
Hi has anybody tried Deplin?

I currently take 5mg of methylfolate every day, in the morning (Thorne 5-MTHF 5mg). It makes a huge difference in terms of my energy levels, both mental and physical. In my opinion, anyone with a chronic disease should address the neurotransmitter issue. Otherwise, depression will eventually ensue.

"Overdosing" on methylfolate works by forcing the methylenetetrahydrofolate reductase (MTHFR) enzyme to work in reverse, recycling BH2 (dihydrobiopterin) back into BH4 (tetrahydrobiopterin). Tetrahydrobiopterin is an essential cofactor in the production of all neurotransmitters.

A cute little video about methylfolate/BH4: L-methylfolate - Mechanism of Action.

And a more technical paper: THE ROLE OF L-METHYLFOLATE IN DEPRESSIVE DISORDERS.