Viral Connection, NAD synthesis: Quinolinic / Kynurenine PathwayCan someone please explain the quinolinic acid part of all of this? It's my understanding that QA is exitotoxic (sp) and/or neurotoxic, and high levels have been found in ME/CFS, parkinson's, MS, etc. My levels were high on an OAT test last spring……….Thanks Anne for starting the thread.
Viruses can affect the NAD Synthesis in the Kynurenine pathway. This is the reason why it's import to supplement to bypass the weak NAD synthesis. The key factor is the NAD+ deficiency, as well as the NADH recycling, anaerobic metabolism (ADP to ATP) imbalance.
Kynurenine Pathway Metabolites in Humans: Disease and Healthy States
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195227/
NAD synthesis , Tryptophan to quinolinate pathway
http://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide
Tryptophan Wikipedia
http://en.wikipedia.org/wiki/Tryptophan
http://forums.phoenixrising.me/index.php?threads/nt-factor-healed-my-cfs.27280/#post-416798
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