Declining anti-inflammatory molecules may play key role in brain aging (and maybe ME)


Senior Member

“SGDGs were first identified in the 1970s, but there were few follow-up studies," explained first author on the new study Dan Tan. "These lipids were essentially forgotten and missing from the lipid databases. Nobody knew SGDGs would be changing or regulated in aging, let alone that they have bioactivity and, possibly, be therapeutically targetable."

What else has been hidden/ignored? I recall the lymph network in the brain that was discovered many decades ago and then forgotten until someone rediscovered it recently. I don't know whether these might be involved in ME, but I don't know that they aren't. You can't look for abnormalities in the levels of these lipids if you don't look for them and don't have a database of what's normal.