Dapsone therapy lyme and co-infections

heapsreal

iherb 10% discount code OPA989,
Messages
9,694
Likes
9,835
Location
australia (brisbane)
Anyone used dapsone alone or in combo with doxy and or rifampin or maybe azithromycin for lyme and co - infections? Going by Dr Horowitz info online it is A very successful drug for the above and I do recall once one is at 100mg per day of dapsone, only 8 weeks is needed to clear lyme and co, so far.

Interested to hear personal experiences.

I feel like I've posted similar article before, probably just cfs dementia????


Cheers👍
 

heapsreal

iherb 10% discount code OPA989,
Messages
9,694
Likes
9,835
Location
australia (brisbane)
Dr Marty Ross talks about it in a short video on his website: https://www.treatlyme.net/guide/dapsone-lyme-persisters
Thanks , I have read abit of Marty Ross's work, he seems switched on. Dapsone sounds promising but also scary if you happen to be one of the people having herx reactions.
I'm currently doing doxy and pulsing flagyl. Flagyl is a tough drug but I feel like I'm in that zone of a herx is a good sign and better than no herx, but I herx on flagyl or rifampin and it smashes my mood. I just wish I knew for sure it was doing something 🤞🙏

Lyme is something I'm really not sure I have. I've tested neg to a lyme test a couple yrs ago here but heard it's only 40% accurate. On dr Horowitz questionnaire I rate high for a tic born disease and have had herx reaction early on in my cfs from low doses of doxycycline etc and can now tolerate doxy well and feel better on it but as I said earlier, flagyl and rifampin smash me.

Dapsone sounds promising because it can be an 8 week treatment and it's all done. If you don't herx it's suppose to have good antiinfammatory effects.
👍
 

kewia

Senior Member
Messages
195
Likes
160
On dr Horowitz questionnaire I rate high for a tic born disease and have had herx reaction early on in my cfs from low doses of doxycycline etc and can now tolerate doxy well and feel better on it but as I said earlier, flagyl and rifampin smash me.
Effects caused by doxycycline can also stem from it's antiviral effect:
In Vitro Antiviral Activity of Doxycycline against SARS-CoV-2
Antiviral activity of doxycycline against vesicular stomatitis virus in vitro
Antimurine retroviral effect of doxycycline
 
Messages
3,525
Likes
6,936
Thank you @heapsreal , Dapsone will be on my drugs list to target neuroinflammation, if my other trials fail :thumbsup:

Dapsone, More than an Effective Neuro and Cytoprotective Drug - PMC (nih.gov) 2022

Dapsone (4,4'-diamino-diphenyl sulfone) is a synthetic derivative of sulfones, with the antimicrobial activity described since 1937

. It is also a drug traditionally used in dermatological therapies due to its anti-inflammatory effect.

In recent years its antioxidant, anti-excitotoxic, and antiapoptotic effects have been described in different ischemic damage models, traumatic damage, and models of neurodegenerative diseases, such as Parkinson's (PD) and Alzheimer's diseases (AD).

Finally, dapsone has proven to be a safe and effective drug as a protector against heart, renal and pulmonary cells damage; that is why it is now employed in clinical trials with patients as a neuroprotective therapy by regulating the main mechanisms of damage that lead to cell death.
 

heapsreal

iherb 10% discount code OPA989,
Messages
9,694
Likes
9,835
Location
australia (brisbane)
Doxy is well known for antiinflammatory effects, probably one of the main reasons it helps cystic acne. But as an antiviral agent, I haven't heard it effective against common cfs viruses like enteroviruses or the herpes viruses like ebv, cmv etc.
It may indirectly treat viruses by treating bacterial infections like mycoplasma and taking the strain off the immune system???
 

heapsreal

iherb 10% discount code OPA989,
Messages
9,694
Likes
9,835
Location
australia (brisbane)

duncan

Senior Member
Messages
2,232
Likes
4,786
@heapsreal , I did dapsone for like six months. In my case, it did not help. Also, as I recall there are potentially some side effects. My memory is bad. But I do recall it mimicked some of the downstream effects of my babesia, e.g. threw my platelets off maybe? or something like hemolytic anemia? Sorry I don't recall. I do remember my doctor and me debating if the symptoms were from dapsone or babs. I maintain to this day they were from babs.
 

heapsreal

iherb 10% discount code OPA989,
Messages
9,694
Likes
9,835
Location
australia (brisbane)
@heapsreal , I did dapsone for like six months. In my case, it did not help. Also, as I recall there are potentially some side effects. My memory is bad. But I do recall it mimicked some of the downstream effects of my babesia, e.g. threw my platelets off maybe? or something like hemolytic anemia? Sorry I don't recall. I do remember my doctor and me debating if the symptoms were from dapsone or babs. I maintain to this day they were from babs.
Yes I've read it can effect folate metabolism which than effects red blood cells etc.
6 months on it wow. Are you still positive for lyme? Obviously didn't seem to help symptoms much if at all??
One thing that interests me about dapsone was that it's effects on folate and how it killed bacteria sound somewhat like bactrim. Bactrim I've found quite helpful while I'm on it buy I only do 10 day courses. Bactrim can treat babs to a certain degree???