Hi i am just wondering what can you do with These results? Does it help in Any Kind for diagnosis?
Not really, at the moment – I only did it so that I could offer my genome for ME research.
There are all sorts of risk factors that tend to show up, but the vast majority will have no impact at all. You'll see things like '1.2% increased risk for X cancer' against one SNP, followed by '1.4% reduced risk for X cancer' against another. Such tiny increases or decreases in risks are too small to be meaningful, and you have to remember that they're calculated using population-wide statistics whose basis could be completely wrong anyway.
This is especially true if the population sampled is largely made up of a different racial group to yours. I have a SNP that causes a 32% increased risk of something quite serious, but only in people of Chinese heritage. No evidence of any effect in other groups. This is quite a common phenomenon – as are cases where an allele represents an increased risk in one racial group, but the opposite allele is the risk in another.
a slight risk of haemochromatosis and therefore I need to be careful with iron because it can build up in the body causing damage
Haemochromatosis is one of the few important conditions that these tests might usefully show up, but by the age of about 35, blood tests should tell you whether you have it or not. I think the report might be saying that some SNPs probably contribute to it, e.g. compound C282Y/H63D heterozygotes, but they're not sure yet about all the possible mutations; and the classic C282Y SNP, which can definitely cause it when homozygous, has variable penetrance.
My mother tested homozygous for the C282Y variant, but died just short of her 90th birthday without ever developing haemochromatosis. Her sister had the disease, but was only diagnosed in late middle age during pre-op tests for routine surgery. She was found to have slight liver fibrosis, but with venesections to keep her iron levels down, she lived perfectly healthily into her 90s. Their uncle, however, died at 56 from liver cirrhosis, presumably caused by undiagnosed haemochromatosis. This is how variable it can be.
A straightforward blood test is the best way to find out what your transferrin and ferritin levels are. I had mine checked a couple of times following my aunt's diagnosis, but it was normal. I now know that I'm only heterozygous for the SNP, so I'm a carrier but will never develop haemochromatosis. It's a common variant in northern Europeans; a sizeable percentage of people with Irish / British ancestry are estimated to be heterozygous for it.