godlovesatrier
Senior Member
- Messages
- 2,363
- Location
- United Kingdom
Cutaneous alpha‐synuclein deposition in postural tachycardia patients
25th March 2021
https://onlinelibrary.wiley.com/doi/10.1002/acn3.51347
Authors
Todd D. Levine, Bailey Bellaire, Christopher Gibbons, Roy Freeman
25th March 2021
https://onlinelibrary.wiley.com/doi/10.1002/acn3.51347
Authors
Todd D. Levine, Bailey Bellaire, Christopher Gibbons, Roy Freeman
Objective
To report a case series of patients with neuropathic POTS and cutaneous phosphorylated alpha‐synuclein (P‐SYN) deposition on skin biopsy and compare these to neuropathic POTS patients without P‐SYN deposition.
Results
Of 296 patients seen with POTS, 22 patients with suspected neuropathic POTS had skin biopsies performed during their evaluation. Seven of 22 patients had P‐SYN present on skin biopsy, while 15 individuals did not. Those with P‐SYN on biopsy: (1) were more likely to be male; (2) had features of REM sleep behavioral disorder; (3) reported less sleepiness and cognitive impairment; and (4) noted greater symptoms of gastroparesis. On autonomic testing, the group with P‐SYN deposition was more likely to have a hypertensive response to tilt‐table testing and abnormal QSART responses.
Last edited: