current OMF-funded research projects underway at the Open House - May 1st 2021

junkcrap50

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junkcrap50

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Just saw this on the CFS subreddit, /r/cfs. Why wasn't this posted on here or shared anywhere else?

Ron Davis spoke first and shared the latest research update on the metabolic trap. I have not viewed the video or his update personally, but others on reddit have reported he said:
  • metabolic trap confirmed in human cells
  • there could be other traps, but this metabolic trap is capable of explaining most problems seen in cfs as well as makes sense with an infectious onset
  • he is now testing drugs on the metabolic trap in yeast cells and this will be a very quick and cheap process
Can anyone else give some brief summaries of each speaker?
 

Alvin2

The good news is patients don't die the bad news..
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I watched the first and second speakers before crashing, they were interesting.
Will have to check out the rest
 

godlovesatrier

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Wish I had known about this one too. Saw someone tweet the summary re metabolic trap findings. This is really great news. I think I might be in this subset.

Fingers crossed he finds some good cheaply available drugs soon.
 

bensmith

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Wish I had known about this one too. Saw someone tweet the summary re metabolic trap findings. This is really great news. I think I might be in this subset.

Fingers crossed he finds some good cheaply available drugs soon.
What are the subsets? Which are you?
 

godlovesatrier

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Nobody knows. But it's clear there's more than one. I find it odd that I had such a good reaction to taking high dose thiamine. As it has no effect on the immune system and I've never had good reactions to anti virals that a metabolic issue might make sense. As I struggled with energy production even as a teenager. I was always the kid who tired easily and felt sleepy a lot.
 

bensmith

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Thanks.

Anybody know long it takes to trial one drug? I hear yeast is fast.

Reddit tells me it should be pretty fast. Months i think
 
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metabolic trap findings.
One theory of my Getting Way Worse...a series of gastro events that seemed in- explicable in 2018. I went from mild to moderately bad- over a few months- post severe stress and two bouts of: near death "stomach flu" that- maybe is no the flu. Or maybe a new virus, not Eppstein-snuck in. I seem to think I'm carrying something that can flare.

But reading that NO3 could have gotten real high during one or both of these events, that could have created a form of: further trapped.

So this trap- well keep working on that theory please, as I think there could really be something to it.

Maybe my decades of mild, I was slightly trapped, or intermittently trapped and then- Ok again. But now: there seems to be NO Ok Again.
 
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As I struggled with energy production even as a teenager. I was always the kid who tired easily and felt sleepy a lot.
I figure my saga started at 1 years of age with the severe food allergies.

I remember how difficult it was for my Dad to get me to wake up to go to school. I don't want to wake up, and I"m 7. And I love school.

Eppstein Barr acute arrived at 10. Then repeated bouts.

In college, I remember I'd get up, cross the room and push the 5 minute snooze alarm- a record was 10 times (fall back to sleep each time your back in bed again).

Visiting friends, slumber parties, us sleeping on some floor- everybody is stepping over me: I'm still not yet awake.

So now I have unrefreshing sleep and when i'm sort of PEM I can- sleep 11 hours (I wake up, just go back to sleep again).
 

godlovesatrier

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Sounds hellish sorry Rufous.

I do wonder how Joshua's herpesveredie paper compares or incorporates metabolic trap into its hypothesis as it's very much mitochondria centric. Which is why I think it might only be one subset. With metabolic trap being another subset.
 

bensmith

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Watched a bit of me video today but I’m too sick atm. Seems pretty reasonable and cool.
 
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