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Cryptolepis sanguinolenta antiviral and antibacterial effects.

heapsreal

iherb 10% discount code OPA989,
Messages
10,046
Location
australia (brisbane)
Abstract
In our biological screening of higher plants, an aqueous and an 80% EtOH extract from the root bark of Cryptolepis sanguinolenta showed potent antibacterial, anticomplementary, and moderate antiviral activities, but no antifungal effect could be detected. Bioassay-guided fractionation of the 80% EtOH extract led to the isolation of three alkaloids: quindoline (1), hydroxycryptolepine (2), cryptolepine.HCl (3), and the corresponding base cryptolepine (4). All compounds strongly inhibited the growth of Gram-positive bacteria (MIC < or = 100 micrograms/ml) and showed a moderate (MIC = 125 or 250 micrograms/ml), a weak (MIC = 500 micrograms/ml), or no activity (MIC > 500 micrograms/ml) against selected Gram-negative bacteria. They also possessed a bactericidal effect depending on the bacterial strain. Compounds 1, 2 and 3 displayed a dose-dependent inhibitory effect on the classical pathway of the complement system while compounds 2 and 3 activated the alternative pathway, except for compound 1. Compound 3 was found to possess an antiherpetic activity. Compounds 1 and 4 showed no antiviral effect, but were quite cytotoxic in the antiviral test system down to a concentration of 1 microgram/ml.
https://pubmed.ncbi.nlm.nih.gov/8720383/

Cryptolepine has potent antiplasmodial activity, and also has anticancer, antifungal, antibacterial, hypotensive, antipyretic, anti-inflammatory and anti-hyperglycaemic activities[299
].
An ethanolic root bark extract showed potent anti-bacterial and moderate antiviral activities. The isolated compounds cryptolepine, hydroxycryptolepine, neocryptolepine, biscryptolepine and quindoline strongly inhibited the growth of Gram-positive bacteria and showed moderate or no activity against selected Gram-negative bacteria. They also possessed a bactericidal effect depending on the bacterial strain[299
].
Cryptolepine was found to possess moderate activity against Herpes simplex virus[299
].
The antibacterial activity of neocryptolepine and biscryptolepine was bacteriostatic rather than bactericidal[299
].
No antifungal activity was observed for the alkaloids against Epidermophyton floccosum, Trichophyton rubrum and Aspergillus fumigatus[299
].
The ethanol extract activity against Campylobacter strains is higher than that of commercial drugs. The ethanol extract and cryptolepine showed some activity against the Vibrio cholerae strains[299
].
https://tropical.theferns.info/viewtropical.php?id=Cryptolepis sanguinolenta
 

heapsreal

iherb 10% discount code OPA989,
Messages
10,046
Location
australia (brisbane)
Sounds like a good allrounder for cfsers that may have multiple infections. With moderate activity against herps simplex, at a guess, it should have some activity against other herpes viruses like ebv/cmv???

Possibly a good combination with artemesia, it could hit multiple bacterial and viral infections???