• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Could I easily make my own topical midodrine cream?

sunshine44

Que sera sera
Messages
1,175
I am a huge fan of transdermal applications. I tolerate much better than orally for many things. Could you try your ratio mixed in some coconut oil? Apply to areas with least amount of hair.
 

marcjf

Senior Member
Messages
127
I am a huge fan of transdermal applications. I tolerate much better than orally for many things. Could you try your ratio mixed in some coconut oil? Apply to areas with least amount of hair.
I think you misunderstood the intent of my post. I am wondering how to prepare that ratio in the first place.
 

Shanti1

Administrator
Messages
3,270
A 0.2% midodrine cream would contain 2mg of midodrine per gram of cream. Following the study dose, if you have 5mg pills, than each one would make 2.5g of cream.

I'm sure the compounding pharmacy added pure midodrine to the vanicream. You have 'pills' (tablets?) that contain excipients. Not sure what the weight of each is but you may want to consider the pill weight as part of the total cream weight.
If you look up its properties, midodrine has decent solubility in water and better in DMSO. I do not believe it is soluble in fat. It is well within the molecular weight that can pass through the skin.
https://go.drugbank.com/salts/DBSALT000250
https://www.selleckchem.com/products/midodrine.html

My thought would be first dissolve the entire pill in as small amount possible of DMSO or DMSO/water mix and then add the well dissolved content to a cream. DMSO has advantages of being a solvent and helping things to cross the skin barrier, but it can be irritating to some peoples skin, so you will have to experiment and make sure to patch test first. Your end product should be 2mg midodrine per g of base (cream).

The study didn't specify how many grams of cream were used with each application. You will want to start with very low amounts and work up since there is no established dosing. Curious if it would provide a more local or systemic effect.
 

marcjf

Senior Member
Messages
127
A 0.2% midodrine cream would contain 2mg of midodrine per gram of cream. Following the study dose, if you have 5mg pills, than each one would make 2.5g of cream.

I'm sure the compounding pharmacy added pure midodrine to the vanicream. You have 'pills' (tablets?) that contain excipients. Not sure what the weight of each is but you may want to consider the pill weight as part of the total cream weight.
If you look up its properties, midodrine has decent solubility in water and better in DMSO. I do not believe it is soluble in fat. It is well within the molecular weight that can pass through the skin.
https://go.drugbank.com/salts/DBSALT000250
https://www.selleckchem.com/products/midodrine.html

My thought would be first dissolve the entire pill in as small amount possible of DMSO or DMSO/water mix and then add the well dissolved content to a cream. DMSO has advantages of being a solvent and helping things to cross the skin barrier, but it can be irritating to some peoples skin, so you will have to experiment and make sure to patch test first. Your end product should be 2mg midodrine per g of base (cream).

The study didn't specify how many grams of cream were used with each application. You will want to start with very low amounts and work up since there is no established dosing. Curious if it would provide a more local or systemic effect.
Thank you very much. This is extremely helpful.