Geez. That’s not promising. Still, I’d rather have vast truth over false hope.
Yeah, from reading some of the threads about 23andme SNP testing on this forum, you can come away with the impression that everything in your health can be explained by your SNPs, and that illnesses can be rectified simply by finding the relevant SNP mutations and then addressing them with compensatory supplements.
But in reality, having been reading these forums for nearly 10 years, in spite of all the exploration and tweaking that people have tried on their SNPs, you rarely find anyone saying: "
Ah, it turns out that all my health problems were due to SNP mutations X, Y and Z, and once I started taking supplements A, B and C to address these, I felt a lot better". Unfortunately that usually does not happen.
I don't regret paying the $100 or so for my 23andme results, because I found it very interesting, and would do it again. But if I were down to my last $100, 23andme would not be what I would spend it on.
The main use of 23andme results on this forum tends to be in an attempt to fine-tune the methylation protocol devised by Rich Van Konynenburg (which involves taking the B12, folate, etc supplements Konynenburg detailed
here).
Konynenburg devised a one-size-fits-all methylation protocol which some have found helps their ME/CFS, and so this may be worth trying. Then you get a few people trying to optimize this methylation protocol using their SNP data. But before you get into all that SNP complexity (which probably will not yield any additional benefit anyway), you might just want to try the simple one-size-fits-all methylation protocol to see if that helps.
Many people on this forum get their methylation-related SNPs interpreted by uploading their raw 23andme data to
Genetic Genie, which provides a free interpretation (similar to your Nutrahacker results above).
Your Nutrahacker results already provide some suggestions for which supplements to try and which to avoid. It's your double mutations (shown in red on your Nutrahacker report) that you mainly want to focus on. When you only have a single mutation (shown in yellow), the effect of that mutation is assumed to be much less. Double mutations are also called homozygous, and single mutations heterozygous.
You might also like to search this forum for people who have the same double mutations as you, and see what they say. Your double mutations are:
COMT H62H (rs4633) —
forum search
COMT V158M (rs4680) —
forum search
MTR A2756G (rs1805087) —
forum search
As an aside, a very new theory about the genetic contributions to disease has been proposed, called
RCCX theory. This is purely a hypothesis at this stage, but it's something worth keeping an eye one. Mutations in the RCCX group of genes are not picked up by 23andme, and indeed the RCCX region of the human genome is a largely unexplored area, but which may have implications for diseases like ME/CFS.
But even with these RCCX region mutations, diseases may only manifest if you catch certain viruses or bacteria, which in combination with some RCCX genetic susceptibility and other factors may lead to disease.