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COMT CBS but not MTFHR! Any advice?


Senior Member
I can´t say what happens in your liver, but your mutations indicate that you have an increased need for B12. Maybe you should have injections daily or every second day with methylcobalamin to get what you really need (my own and others experience with fewer mutations) . At least your mutation show that you, without b12 supplementation, might have a blocked methylation and lowered level of reduced glutathione as described by Rich Van Konynenburg.

I read somewhere here that Jarrows isn´t longer as effective as before. People changed brand to ?. I think you should take some folate (you don´t need the bioactive ones as far as I can see) together with the B12 as they co-work. Best of luck!