Complete Symptom Relief and CFS Remission Since Starting Nitric Oxide Supplement

gregh286

Senior Member
Messages
980
Location
Londonderry, Northern Ireland.
Strangely enough my nitric oxide levels seem ok via the NO strips when off the NO2 black.
I think the NO2 is "force opening" the smaller vessels.

Kdm was of opinion that the lyme biofims attached to inner vessel wall inhibiting vessel flexibility and clogging up microcirculation. I think it was fluge and mella or the newcastle team who noticed the vessels had less flex when depressed then reopened. There.was a study on it from memory.

I am glad you got some benefit @JES
 

clive powney

Senior Member
Messages
206
Location
coventry
Hi,
I've been on here a few years. Like most I have tried nearly every supplement there is, mostly a lot of rubbish.
On Feb 5th I started a product called MRI No2 Black.
http://mri-performance.com/products/no2-black/




I would encourage anyone to try it and maybe we can do a poll later, prehaps better to all use same product to rule out brand variance.

Fluge and Mella haven't taken out a patent for no2 treatment in CFS for nothing.

Hi Gregh286,
I am becoming more and more intrigued by this vaso dilation idea , the more I read. I am looking at trying this product but have a couple of questions:

where is the fluge and mella paten for no2 patent - I can see one for generalised NO treatment?

is there any evidence on long term use of no2 and my reservations on things like strokes or other problems with too over dilation of blood vessels?
thanks in advance
Clive
 

gregh286

Senior Member
Messages
980
Location
Londonderry, Northern Ireland.
Hi Gregh286,
I am becoming more and more intrigued by this vaso dilation idea , the more I read. I am looking at trying this product but have a couple of questions:

where is the fluge and mella paten for no2 patent - I can see one for generalised NO treatment?

is there any evidence on long term use of no2 and my reservations on things like strokes or other problems with too over dilation of blood vessels?
thanks in advance
Clive

http://www.google.com/patents/EP2805730A1?cl=en
http://forums.phoenixrising.me/inde...ith-or-without-b-cell-depletion-in-cfs.36592/

I think the danger of strokes would be higher without vasodilation. I.e hypertension etc.
 

clive powney

Senior Member
Messages
206
Location
coventry
Gregh286,
Reading your posts , your pathway to sickness seems to be quite close to mine. I was a very sporty person and was still v fit at around 39 - probably doing too much. I then got shingles and I had a funny turn on a squash court whereby my body panicked and I thought i was having a heart attack. Same thing happened about 3 weeks later whilst running. Things went down hill gradually over the next 6 to 7 years , starting with my balance and inability to recover after activity. Panic attacks in the night and night sweats, feeling sick and tired with minimal exercise and I eventually had to give up work. Stress was always an issue which my body couldnt cope with and this all led to a sort of depression , based on the feeling of losing the person I was and no-one believing me. I am now sort of OK unless I do too much, too much might be cutting the lawns or washing the car. I dont spend days and days in bed anymore but I dont really have particularly good days now either, just plodding along. I have now been ill for 14 years and have always wondered why alcohol makes me feel better. My mates down the pub (when I manage to get out) think it is all in my head , cos when I drink I feel so much better. I hadnt realised that there seemed to be a subgroup who felt better on alcohol, until the last few days - I always thought i was the odd one out and was MAYBE not suffering from ME/CFS as everyone else seemed to have an intolerance to alcohol and had low BP , whereby my BP is high and I need tablets to keep it under control. If I try NO2 I was wondering if i should mybe stop BP meds and just keep an eye on it daily and if it goes back up to restart. My BP isnt disasterous and is only 150 /95 off meds and 120/80 on meds.
I noticed you mentioned pins and needles in your hands and feet in the morning as well, which I get all the time. Strangely though my feet can be too hot sometimes also - especially at nigh before I go to bed. My wife uses them as a radiator for her cold feet, which I dont mind as it makes mine feel better
 

gregh286

Senior Member
Messages
980
Location
Londonderry, Northern Ireland.
Gregh286,
Reading your posts , your pathway to sickness seems to be quite close to mine. I was a very sporty person and was still v fit at around 39 - probably doing too much. I then got shingles and I had a funny turn on a squash court whereby my body panicked and I thought i was having a heart attack. Same thing happened about 3 weeks later whilst running. Things went down hill gradually over the next 6 to 7 years , starting with my balance and inability to recover after activity. Panic attacks in the night and night sweats, feeling sick and tired with minimal exercise and I eventually had to give up work. Stress was always an issue which my body couldnt cope with and this all led to a sort of depression , based on the feeling of losing the person I was and no-one believing me. I am now sort of OK unless I do too much, too much might be cutting the lawns or washing the car. I dont spend days and days in bed anymore but I dont really have particularly good days now either, just plodding along. I have now been ill for 14 years and have always wondered why alcohol makes me feel better. My mates down the pub (when I manage to get out) think it is all in my head , cos when I drink I feel so much better. I hadnt realised that there seemed to be a subgroup who felt better on alcohol, until the last few days - I always thought i was the odd one out and was MAYBE not suffering from ME/CFS as everyone else seemed to have an intolerance to alcohol and had low BP , whereby my BP is high and I need tablets to keep it under control. If I try NO2 I was wondering if i should mybe stop BP meds and just keep an eye on it daily and if it goes back up to restart. My BP isnt disasterous and is only 150 /95 off meds and 120/80 on meds.
I noticed you mentioned pins and needles in your hands and feet in the morning as well, which I get all the time. Strangely though my feet can be too hot sometimes also - especially at nigh before I go to bed. My wife uses them as a radiator for her cold feet, which I dont mind as it makes mine feel better

Hi clive.
Yea we seem to be in same subgroup. My bp is around 130/80 at rest. Same on standing. I take amlodipine same.time as NO2 black no probs. Doc was reluctant to give me amlodopine as normal to use it when bp nears 160/90 but i said it helps me sometimes.
All dilators do the trick for me carbs (insulin), NO donors, sauna, hot bath. Red wine is the most powerful.

Last year i travelled to seychelles in may...by the time i got there i was absolutely mangled from travelling. It was around 34c and 75% humidity. As soon as i hit the heat i could feel the lactate leaving within a few hours i was totally renewed. Best week i had in ages. I am still considering moving abroad.

Something is wrong in the mechansim of vasodilation. In kdm clinic my bp shot to 250/90 in light exercise. Its not normal by any stretch of imagination.

NO2 black is only masking the underlying issue. Personally i think i have some bacterial overgrowth on small vessels keeping them rigid....in hot humidity they become flexible again.....much like when you heat glue it softens.
Maybe kdm is right all this time and its a lyme issue.

NO2 black allows me to play 18 holes golf now no probs. I am tired at end but it has enabled me to recapture some of my life.
Before cfs i was doing half marathons etc at a breeze.
 
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clive powney

Senior Member
Messages
206
Location
coventry
Hi clive.
Yea we seem to be in same subgroup. My bp is around 130/80 at rest. Same on standing. I take amlodipine same.time as NO2 black no probs. Doc was reluctant to give me amlodopine as normal to use it when bp nears 160/90 but i said it helps me sometimes.
All dilators do the trick for me carbs (insulin), NO donors, sauna, hot bath. Red wine is the most powerful.

Last year i travelled to seychelles in may...by the time i got there i was absolutely mangled from travelling. It was around 34c and 75% humidity. As soon as i hit the heat i could feel the lactate leaving within a few hours i was totally renewed. Best week i had in ages. I am still considering moving abroad.

Something is wrong in the mechansim of vasodilation. In kdm clinic my bp shot to 250/90 in light exercise. Its not normal by any stretch of imagination.

NO2 black is only masking the underlying issue. Personally i think i have some bacterial overgrowth on small vessels keeping them rigid....in hot humidity they become flexible again.....much like when you heat glue it softens.
Maybe kdm is right all this time and its a lyme issue.

NO2 black allows me to play 18 holes golf now no probs. I am tired at end but it has enabled me to recapture some of my life.
Before cfs i was doing half marathons etc at a breeze.
I was tested positive for lyme approx 10 years ago in both an Amercan and German lab and was on ABX for over 2 years - all sorts of variations , but they never really worked and I continued to decline. red wine is a favourite of mine for relief and as you have said, if I travel abroad in the heat I always feel much better. I will try the no2 out, but I am a bit of a chicken and will start with 2 tabs split across the day and raise it by 2 every couple of days until I get to 8.
 

gregh286

Senior Member
Messages
980
Location
Londonderry, Northern Ireland.
I was tested positive for lyme approx 10 years ago in both an Amercan and German lab and was on ABX for over 2 years - all sorts of variations , but they never really worked and I continued to decline. red wine is a favourite of mine for relief and as you have said, if I travel abroad in the heat I always feel much better. I will try the no2 out, but I am a bit of a chicken and will start with 2 tabs split across the day and raise it by 2 every couple of days until I get to 8.

Yea i tested positive at armin. Wasnt a shocker as everyone seems ++ there. Abx dont seem to have significant effect. Aspirin a good tool in the armoury. Blood thinners obviously boosting sluggish circulation or overcoming endothelium friction. I often wondered is to possible to test endothelium/blood friction resistance. At times i often thought.cfs was the endothelium becoming more frictional.....this in turn creates the blood flow issue and distribution.
 

gregh286

Senior Member
Messages
980
Location
Londonderry, Northern Ireland.
I was tested positive for lyme approx 10 years ago in both an Amercan and German lab and was on ABX for over 2 years - all sorts of variations , but they never really worked and I continued to decline. red wine is a favourite of mine for relief and as you have said, if I travel abroad in the heat I always feel much better. I will try the no2 out, but I am a bit of a chicken and will start with 2 tabs split across the day and raise it by 2 every couple of days until I get to 8.

You should try ldn. There is a good facebook group on ldn for cfs. I started it jan 15th.
 

clive powney

Senior Member
Messages
206
Location
coventry
You should try ldn. There is a good facebook group on ldn for cfs. I started it jan 15th.
I have tried ldn about 7 or so years ago - no luck whatsoever. I might look into aspirin, although there have been some issues with long term use from what I remember.
 

drob31

Senior Member
Messages
1,487
This reminds me of "sticky" blood with antiphospholipid syndrome. Have you been tested for APA?
 

Battery Muncher

Senior Member
Messages
620
I was curious to try No2 Black because I regularly experience phases of what seems to be spontaneous vasodilation and a raging thirst.

I can categorise these episodes into three situations but I can only recognise a trigger for one of them:
  • if I've been active, particularly shopping but not exclusively, fatigue can hit like a wave and I get a sudden raging thirst. Sometimes it's the thirst which hits first. I will typically knock back at least two, sometimes three, pints of water and half an hour later the worst of the fatigue will have passed. From time to time, I even get a boost of energy.
  • quite often in the evening, after drinking adequately and peeing normally all day, I'll get a sudden thirst and drink a pint of liquid. Half an hour later, the thirst might return and I'll drink another pint, and possibly again another half hour later. I may not pee again before bedtime and in the morning very little, but over the day I'll excrete more fluid than I take in. By the evening, the raging thirst will be back.
  • over periods which can last weeks or months, I get very, very thirsty overnight to the extent that I keep waking up to drink typically 100 to 200 ml of water but in the morning I don't pee out anything like the expected volume. During these nights, I'm listless/restless and weak. My blood pressure is typically below 100/60, not drastically low but low enough to feel it.
The process is unpleasant, sometimes extremely so, but the end result feels good (except in the overnight scenario which ends in the usual morning 'hangover'). It doesn't surprise me that some people are reporting unpleasant effects from the No2 Black.

I started the No2 on Monday pm so that I would get a half dose the first day. Monday wasn't remarkable at all. Tuesday was grim; by midday my vision was blurry and I couldn't think straight. I drank plenty of fluid but couldn't seem to absorb as much as I needed to. Even so, I had put on 2lb by the end of the day. Wednesday was somewhat better with improving vision but I still couldn't muster the effort to do the dishes. My feet felt weirdly engorged and warm with blood and slightly itchy in the same way that a healing scab is, rather than a rash.

On Thursday I sweated profusely in the morning (very unusual). Later on I took my mother out for her shopping and had to drag myself around the shop. My limbs seemed much heavier than usual. In the evening, I noticed that my vision was particularly good. I still had the strangely blood engorged sensation in my feet, and the right one especially was all veiny.

Today, I'm back at baseline in all respects except that my vision is much, much better and the skin on my hands and face feel moisturised. And the dishes are now done. As of this morning I was still 2lbs heavier.

No miracle so far but having forced myself through the tough part I'm going to persevere in the hope that the benefits are still to come.

Thank you for your interesting and detailed post.

I was wondering if you could expand on the changes to your vision.

What is your vision usually like?
Do you have visual snow?
And what is it like now - clearer? Sharper? Do you perceive colours differently?
 

Scarecrow

Revolting Peasant
Messages
1,904
Location
Scotland
What is your vision usually like?
Do you have visual snow?
The problems I am aware of are:
  • blurry vision as if my prescription is not quite right (acuity?)
  • visual snow, always present but I don't notice it too much unless it's particularly bad
  • difficulty with accommodation when moving from reading distance to medium or long distance (but not vice versa)
  • the world appears "flat". i.e. poor perception of 3 dimensions (probably more to do with a faulty brain than faulty eyes)
I've previously found that piracetam improves all of the above but over recent months I've been taking it infrequently because I wasn't getting the same cognitive benefits that I once had.

Initially, for the first day on the No. 2 black, it felt like there was a film over my eyes but on the second day I noticed that acuity and colour intensity were much improved. I wasn't aware of any change in 3D perception.

Today I've added in piracetam and my vision is as good as it gets; colours are popping, 3D perception is amazing and the enhanced acuity means that I pick up on the texture of, for example, the wallpaper in my kitchen, which doesn't usually attract my attention. Visual snow is minimal.
 

gregh286

Senior Member
Messages
980
Location
Londonderry, Northern Ireland.
As I delve deeper into NO and dysfunction in the endothelial cells, I have noticed quite a number of papers have connected high uric acid and poor NO status, example of 2;
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701227/
http://www.sciencedirect.com/science/article/pii/S0735109701016436

As NO donors are a particularly successful treatment in my case of CFS, looking back my Uric acid in KDM was 8.0mg/dl, quite a way above the target of 5mg/dl, he subsequently proposed allopurinol for 3 months. Much to my GPs disgust I may add, as allopurinol is used for gout, even though NHS max of range is 7.4mg/dl.

So, I have started the allopurinol for 3 months and will remeasure the Uric acid level at the end of the 3 month period to see if it has dropped significantly will be interesting to see whether NO2 black is still an essential at the end.
It should be interesting to see any effect on blood pressure also.

Keep the faith.:)
 

JPV

ɹǝqɯǝɯ ɹoıuǝs
Messages
858
Yeah, I remember having a test done, years ago, showing that I have high uric acid. Probably something I should look into.
 
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JPV

ɹǝqɯǝɯ ɹoıuǝs
Messages
858
As I delve deeper into NO and dysfunction in the endothelial cells, I have noticed quite a number of papers have connected high uric acid and poor NO status,
Somehow, whatever issues I'm dealing with always seems to come back to candida...
Candida albicans suppresses nitric oxide (NO) production by interferon-gamma (IFN-γ) and lipopolysaccharide (LPS)-stimulated murine peritoneal macrophages

The major findings of the present study were: (i) Candida albicans suppressed the production of NO and iNOS mRNA expression by IFN-γ and LPS-stimulated macrophages; and (ii) such inhibition was mediated mainly by soluble molecules derived from Candida albicans and to a lesser extent by direct contact between the fungus and macrophages; but (iii) not by IL-10 and TGF-β derived from macrophages.
Candida And Inflammation

The byproducts produced by Candida include acetaldehyde, ammonia and uric acid. These harmful substances (along with a long list of other toxins) can enter your bloodstream and cause a host of diverse symptoms. An inflammatory response is your body’s way of dealing with Candida and its byproducts. This inflammation contributes to many of the symptoms regularly associated with Candida.
 
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