Complete Symptom Relief and CFS Remission Since Starting Nitric Oxide Supplement

Justin30

Senior Member
Messages
1,065
I used to work as a manager in a supplement store for bodybuilders 11 years ago when AAKG fist came out.

It differs in potency over argine dramatically as the alpha ketoglutarate molecule the arginine is bonded to is readily uptaked into the cells. Way more potent than L Arginine.

These products used to make my veins huge.

Arginine if taken in high doses and you have HSV-1 or 2 will ellicit outbreaks as it disturbs the balance between Lysine. HSV 1 and 2 lay dormant in the CNS until they shed into the bloodstream and cause an outbreak. I dont know how this plays a role in CMV,HHV6,7,EBV,etc.

My concern is that with weakened immunity and people that have HHV viruses active or inactive from Antivirals therapy that this could trigger the shedding of the virus. HHV viruses have not been studied thoroughly in ME/CFS but we know they reactivate and trigger ME.

Further POTS and other forms of OI have not been solved. I tried AAKG when I first got sick and it didnt do nothing which told me I had something that was messing with my biological processes.

Now that I have ME at 30 years old and you told me I could take AAKG and solve my 50 symptoms I would say know way.

If I was a less severe case or lets say mild I would try it and would probably see benefits. I have used many BB supplements to try to increase energy with mild success.

True ME is neurological and immunological and extremely debilitating. I have several weird abnormalities that in no way an amino acid could rectify. I have been to a top CFS Specialist as well.

I Inject taurine with mild benefits. Low taurine = low NO. I do this daily.

I used AAKG on my dad after his 6 bypass surgery combined with creatine and it resolved his high blood pressure and he was able to get off meds. It continues to work. His Dr Ok'd it.

@gregh286 I am happy for you finding that this works so well.

Your fortunate to not have OI
 

gregh286

Senior Member
Messages
980
Location
Londonderry, Northern Ireland.
Hi justin.
Yea consider myself lucky to have borderline high blood pressure without POTS/OI so NO boosters fit profile.
I agree my veins stand up like mad after ingestion of NO2 black. I still think i am just shortcutting my underlying problem with NO2 black...low taurine maybe a plausible issue also.
Regarding neuro and immuno problems...the stresses and strains of ME does create additional symptoms that i have well and truly experienced also in past although not daily....feeling of impending doom....recurring infections....racing heart...brain fog.etc etc.
If you told.me amino would help me i also would have dismissed it totally a year ago. Symptoms were just too far ranging.
 

Justin30

Senior Member
Messages
1,065
Thats great to here. I am glad that you got an affect from it. If you have seen such good results from it and don't have any other kidney issues,etc. using Creatine with it can work synergistically with it.

When I used it, it literally made me be able to double what I could normally do in the gym. But when used either just creatine or just arginine not the same affect. My experience is that your body adapts to the amout of arginine taken. I would have to start and stop for a month in between to keep the affect or switch to L Arginine. Quality and purity make a big difference with any amino acid.

Creatine Monhydrate, creatine ester, creatine malate. Etc.

I dont know if you have tried creatine. Creatine, citruline and arginine those together work well....boost NO and ATP.

Did you take any Antivirals, ABX, Immune modulators to help your situation out....prior too...meeting AAKG?
 

gregh286

Senior Member
Messages
980
Location
Londonderry, Northern Ireland.
Hi.
No didnt try creatine yet.
When i got my amino results i was deficient in arginine, tyrosine, taurine, glycine and glutamine. Creatine and citrulline was good so i focused on what i needed.

I was on abx for months...ex-patient of.KDM whom everyone he treats has ""chronic lyme""..tried valtrex and i continue to use LDN and lactoferrin for immune. All abx.do is screw up your gut. Valtrex i didnt see any upside.
I always figured my cfs was metabolic/circulation based not viral or.bacterial as i would get very fast remissions when using vasodilators. Virus or.chronic infection not clear instanteously like that.
 

TiredSam

The wise nematode hibernates
Messages
2,677
Location
Germany
This experiment is over for me. That stuff wipes me out - I only took one this morning, put me too sleep and left me feeling groggy all day, just like yesterday. If I'm going to spend all day feeling exhausted and headachy I'd rather it was my good old ME exhaustion and headache that I'm familiar with, I don't need a whole new foggy feeling in my head and more exhaustion on top of it.

Anyway thanks @gregh286 for sharing, it was worth a try. And if nothing else, this thread has shown me that after months of alcoholic abstinence I can enjoy red wine and even feel pretty good the next day, so I'll continue experimenting with that.

I hope someone else gets some benefit from NO2 black.
 

gregh286

Senior Member
Messages
980
Location
Londonderry, Northern Ireland.
This experiment is over for me. That stuff wipes me out - I only took one this morning, put me too sleep and left me feeling groggy all day, just like yesterday. If I'm going to spend all day feeling exhausted and headachy I'd rather it was my good old ME exhaustion and headache that I'm familiar with, I don't need a whole new foggy feeling in my head and more exhaustion on top of it.

Anyway thanks @gregh286 for sharing, it was worth a try. And if nothing else, this thread has shown me that after months of alcoholic abstinence I can enjoy red wine and even feel pretty good the next day, so I'll continue experimenting with that.

I hope someone else gets some benefit from NO2 black.

Sorry to hear that tiredsam....guess its not going to be panacea for all. Hope you bounce back soon.
 

MEPatient345

Guest
Messages
479
I have ordered some and will try gradually next week. I am severe, and have OI, POTS, normal to low BP, so I shall have to be v careful.. The only thing I have slight benefit from is LDN so far. Sorry to see it didn't work for tiredsam.
 

Lynn

Senior Member
Messages
366
I am on day two. I took 6 pills/day.

Definitely no miracle cure for me. What's really weird is that one of the reasons I decided to try this is I have high blood pressure. I am monitoring that. Ironically, this supplement is raising my pressure systolic by 25 points and diastolic by 10. I thought it would lower it. I feel wiped out and head achy. I am going to give it one more day.

Unfortunately, I am no longer expecting a short term positive effect. Bummer!

Lynn
 

ryan31337

Senior Member
Messages
664
Location
South East, England
I came across something today that I found interesting, the title of the research says it all really:

Salt Inactivates Endothelial Nitric Oxide Synthase in Endothelial Cells
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646221/

Relevant to those with OI that have been taking a lot of salt for extended periods. Perhaps the knock-on effect of low NO is causing more problems in the long run?
 

TiredSam

The wise nematode hibernates
Messages
2,677
Location
Germany
I came across something today that I found interesting, the title of the research says it all really:

Salt Inactivates Endothelial Nitric Oxide Synthase in Endothelial Cells
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646221/

Relevant to those with OI that have been taking a lot of salt for extended periods. Perhaps the knock-on effect of low NO is causing more problems in the long run?
That's interesting. I have OI, but not POTS, and put salt on anything and everything. My blood pressure was 95/67 today. Apart from headaches and fogginess, the NO2 black made my arms and hands tingle. I don't know what all that means, but I assumed it meant that I was getting too much of something.

EDIT: Blood pressure now written correctly :jaw-drop:
 
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JES

Senior Member
Messages
1,392
Has anyone tried straight AKG?

I have now been taking it for a couple of days while waiting for NO2 Black to be shipped. The effects are quite interesting, definitely more powerful than standard Arginine on same dosage. With 1250 mg AAKG twice daily, I notice much bigger veins and my chronically cold hands are not cold anymore. Chronic anxiety has improved as well and heart rate seems to raise less when standing. Too early to speculate more at this point, but at least it has some concrete effects.
 

Jon_Tradicionali

Alone & Wandering
Messages
291
Location
Zogor-Ndreaj, Shkodër, Albania
I've tried 10g liquid form AAKG along with 10kg Citrulline once daily, along with an "NO booster" which had L-Norvaline and a few other NO 'boosting' ingredients.

I did this after the Fluge/Mella patent was filed.

Apart from large veins and a body which looks like a mid twenties Schwarzenegger, no other effects noticed. It's quite ironic I look so fit because I gasp for air after climbing a set of stairs and have never done bodybuilding.

Regardless, this works for some but not for others. It has something to do with Nitric Oxide. That's all we know at this point.
 

JPV

ɹǝqɯǝɯ ɹoıuǝs
Messages
858
i continue to use LDN and lactoferrin for immune.
I wonder if there is some synergistic effect going on with your regimen.

Other than LDN and lactoferrin, do you mind listing what else you're currently taking?
 

JES

Senior Member
Messages
1,392
I stumbled upon another supplement: Agmatine, which is closely related to L-Arginine. PR thread and article about its mechanism here. From browsing a couple of forums, it seems body-builders prefer Agmatine over AAKG, so it might in theory provide even more NO benefits. It's surely something worth trialing as well for those who benefit from AAKG.
 

gregh286

Senior Member
Messages
980
Location
Londonderry, Northern Ireland.
I wonder if there is some synergistic effect going on with your regimen.

Other than LDN and lactoferrin, do you mind listing what else you're currently taking?

Ldn 4.5mg since jan 15th.
Lactoferrin 250mg x 4
Nutri adrenal extra x1
No2 black x10
Niacin 1500mg slow release
B12 adeno 3000mg
B12 methyl 5000mg
Methlyfolate 800mg
Protein shakes pHD brand x2
P5P 100mg
N acetyl tyrosine 350mg x4.

So yes its possible its reacting with something else.
 
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