Complete Symptom Relief and CFS Remission Since Starting Nitric Oxide Supplement

[gregh286]

Just to clear up in my mind. You take a total of 10 tablets of the No2 Black ? If I am looking at the correct product , directions call for 3 tablets a day.

Thanks for all your info on this. Billt

8 a day is the dosing schedule for male <200lbs. 10 tabs for male >200lbs.

 

[Billt]

8 a day is the dosing schedule for male <200lbs. 10 tabs for male >200lbs.

Thanks for clearing that up. Well worth the try for my son. Is a bit costly but if it can ( possibly ) help his energy level we will give it a try. Like you, nothing else has helped him. Did you start out with the full dose or work up to it ?

 

[gregh286]

Thanks for clearing that up. Well worth the try for my son. Is a bit costly but if it can ( possibly ) help his energy level we will give it a try. Like you, nothing else has helped him. Did you start out with the full dose or work up to it ?

No...im all in or nothing type of person.
Straight in with the 10 on day 1.

 

[Billt]

No...im all in or nothing type of person.
Straight in with the 10 on day 1.

Sound like me ! Thanks again buddy. Hope it continues to work well for you and maybe we can get more on here to let us know. When we get ours I will post results ! fingers crossed...

 

[JES]

I will start experimenting with AAKG and ActiNOS boosted AAKG asap to compare if there's any difference. The only big concern I have with these supplements is tolerance. From what I recall reading, most of the NO boosting supplements and medications quite quickly develop tolerance. This unfortunately makes my gut feeling a bit less positive about the chances of getting any long-term benefits.

 

[kangaSue]

I will start experimenting with AAKG and ActiNOS boosted AAKG asap to compare if there's any difference. The only big concern I have with these supplements is tolerance. From what I recall reading, most of the NO boosting supplements and medications quite quickly develop tolerance. This unfortunately makes my gut feeling a bit less positive about the chances of getting any long-term benefits.

Folic acid supplementing is said to help to overcome nitrate tolerance.
http://www.ncbi.nlm.nih.gov/pubmed/12548078

 

[JPV]

Folic acid supplementing is said to help to overcome nitrate tolerance.

Yeah, @Hip had written about this in a previous thread regarding NO. He also mentioned that BH4 and L-5-MTHF may help too...

Folic Acid Prevents Nitroglycerin-Induced Nitric Oxide Synthase Dysfunction

This study found that folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction; the authors hypothesis that tetrahydrobiopterin (BH4) is involved. And this study demonstrates that folic acid reverses the endothelial dysfunction induced by BH4 depletion.

So folic acid and BH4 supplementation may help nitroglycerin regain its vasodilating effect. You can buy BH4 in 2.5 mg capsules at these places: 1, 2, 3, 4. But 2.5 mg is quite low compared to the 100 mg found in the prescription BH4 medication called Kuvan. This paper says sauna may help raise BH4. I understand that BH4 is sensitive to degradation by free radicals, so you would be advised to take antioxidants when you take BH4.

More info on BH4 as an essential cofactor for the activation of nitric oxide synthase is found in this article. It mentions that methylfolate (L-5-MTHF) may help substitute for BH4 when BH4 is deficient.

 

[hvac14400]

my envy to people with high blood pressure is so strong, lol.
is there any way to actually reduce NO production? : )

 

[gregh286]

I will start experimenting with AAKG and ActiNOS boosted AAKG asap to compare if there's any difference. The only big concern I have with these supplements is tolerance. From what I recall reading, most of the NO boosting supplements and medications quite quickly develop tolerance. This unfortunately makes my gut feeling a bit less positive about the chances of getting any long-term benefits.

Tolerance prehaps develop if you are starting from a normal NO base point....body sees too much NO coming in and deals with it accordingly. In case of low NO, body should not reject excess NO until we reach a homeostatic NO point.

 

[Seven7]

It is quite possible, though, that the benefits of the MRI NO2 Black supplement for ME/CFS do not come so much from its arginine alpha ketoglutarate ingredient, but more from the ActiNOS® ingredient, which the blurb says is scientifically proven to raise nitric oxide synthase (NOS) by 950%.

NOS is the body's enzyme which makes NO. The NOS enzyme makes NO starting with arginine as a raw material. So you need both arginine and NOS to produce NO.

Several body-building supplements contain this NOS-boosting ActiNOS ingredient, including these:

MRI - NO2 BLACK — ActiNOS content not given, but each 3 gram serving includes a proprietary blend of 150 mg of alpha lipoic acid + ActiNOS.

MRI - Pro-NOS — ActiNOS content not given.

Amix Nutrition - CFM Nitro Protein Isolate — contains 425 mg of ActiNOS per 100 grams of powder.

Reflex Nutrition - NOS Fusion — 1390 mg of ActiNOS per 100 grams of powder.

Pro Line Nutrition - Iso-Advanced Whey Protein Isolate — ActiNOS content not given.

Extrifit Sport Nutrition - Actinox Nitro Peptides — 1522 mg of ActiNOS per 100 grams of powder (I think).



ActiNOS is a whey-derived peptide fraction. ActiNOS was developed by a company called Glanbia Nutritionals. I think the scientific name for ActiNOS is nitric oxide peptide-47 (NOP-47). Their info page on ActiNOS / NOP-47 is here. To quote:

The study they are referring to in the above quote is this one.

I have a question

AAKG is a natural blood thinner so people taking blood thinners should use with caution. Some doctors believe that people with any form of the herpes virus (cold sores or genital herpes) should not consume AAKG as it may induce virus symptoms. Quote from: http://www.mensfitness.com/nutrition/supplements/supplement-guide-aakg

Has anybody with herpes tried this? My curse is hh6v I don't want to go backwards. But sounds interesting to try since POTs is so bad for me.

 

[TiredSam]

I've just read through 10 pages of amazon reviews. Summary of main points:

A few reviewers advise starting off with 2 tablets instead of 4-5, seeing how that goes, and raising the dose by 1 after a week if necessary. Drink lots of water (box says 2 litres a day on full dose). Avoid coffee and caffeine while taking the tablets, as they will diminish the effect. Some people get headaches and stomach upset on a full dose, or when starting off taking the tablets. Couple of reviewers say consider cycling the tablets, ie 3 weeks on, 1 week of.

The above advice is from the perspective of body-builders, but it may be useful for us too.

Couple of good PR articles from 2014 on Nitric oxide here:

http://phoenixrising.me/archives/18836
http://phoenixrising.me/archives/25528

Good luck everyone trying this out

 

[JES]

I have a question

AAKG is a natural blood thinner so people taking blood thinners should use with caution. Some doctors believe that people with any form of the herpes virus (cold sores or genital herpes) should not consume AAKG as it may induce virus symptoms. Quote from: http://www.mensfitness.com/nutrition/supplements/supplement-guide-aakg

Has anybody with herpes tried this? My curse is hh6v I don't want to go backwards. But sounds interesting to try since POTs is so bad for me.

The blood thinning property could actually be useful, as many CFS patients have thick blood (very low ESR reading on lab tests).

From what I've read, Arginine could well worsen existing herpes outbreaks for those who are prone to it. I think CFS is, however, quite different from a healthy person battling herpes viruses, evidenced by the fact that few CFS patients seem to get much or any help from standard antiherpesvirals. I've tried Arginine (although at small dosage) couple of times before and never noticed any worsening in CFS symptoms, so I wouldn't be too worried if you increase the dosage slow.

 

[CFS_for_19_years]

Thought I'd share a marketing email I received from vita4less.com; I'm not affiliated with them in any way:

Mri NO2 Black, 180 tablets for $34.52
Offer expires 4/6/16 at 12:00 AM Pacific Time (California)
Free shipping for orders over $35

They also offer international shipping, international delivery takes between 2 to 4 weeks, prices available at checkout.

Save $10 off any order $59 or more, by using Promo code PROMO109 (109 = one zero nine)
Save $20 off any order $99 or more, by using Promo code PROMO204 (204 = two zero four)

Yes, as far as I can make out the main drawbacks mentioned are:
1) The pills are pretty big, so might need a pill cutter

A lot of extended-release medications have instructions that say DO NOT CUT THE TABLETS, otherwise you might lose some of the extended-release benefit, and then risk having a lot of the medication dumped into your system all at once.

I didn't see any instructions on boxes of NO2 Black regarding cutting the tablets, but I think cutting them might possibly defeat some of the extended-release properties.

 

[gregh286]

The blood thinning property could actually be useful, as many CFS patients have thick blood (very low ESR reading on lab tests).

From what I've read, Arginine could well worsen existing herpes outbreaks for those who are prone to it. I think CFS is, however, quite different from a healthy person battling herpes viruses, evidenced by the fact that few CFS patients seem to get much or any help from standard antiherpesvirals. I've tried Arginine (although at small dosage) couple of times before and never noticed any worsening in CFS symptoms, so I wouldn't be too worried if you increase the dosage slow.

Hi.
I was always under impression low esr was indicative of thicker blood. This is not the case my GP explained.to me...low esr is better. esr is the function of the plasma seperating from the serum in the tube. (Distance of seperation/time)
Incidentally mine is 2-3 mostly.

 

[gregh286]

I've just read through 10 pages of amazon reviews. Summary of main points:

A few reviewers advise starting off with 2 tablets instead of 4-5, seeing how that goes, and raising the dose by 1 after a week if necessary. Drink lots of water (box says 2 litres a day on full dose). Avoid coffee and caffeine while taking the tablets, as they will diminish the effect. Some people get headaches and stomach upset on a full dose, or when starting off taking the tablets. Couple of reviewers say consider cycling the tablets, ie 3 weeks on, 1 week of.

The above advice is from the perspective of body-builders, but it may be useful for us too.

Couple of good PR articles from 2014 on Nitric oxide here:

http://phoenixrising.me/archives/18836
http://phoenixrising.me/archives/25528

Good luck everyone trying this out

Great article, pretty much the mechanics of CFS "fatigue" explained perfectly. http://phoenixrising.me/archives/25528
The instigator of the NO dysfunction is still a mystery, autoimmunity still the front runner in many of the leading minds.
I am also of the belief hormones are still part of the overall picture...sex hormones have implications in other autoimmune disorders, SLE, etc. Ratio of male/female similar to CFS also. Periods of remission reported during pregnancy etc,
dr coimbra protocol of 100,000 ui Vit D units a day supposed to have high success rate in autoimmune disorders.
Surprised it doesnt have more "activity" on Phoenixrising.

http://www.vitamindandms.org/researchers/coimbra/
http://forums.phoenixrising.me/inde...min-d-protocol-for-autoimmune-diseases.34777/
http://www.thisisms.com/forum/coimbra-high-dose-vitamin-d-protocol-f57/topic27151.html

 

[JPV]

I thought this was very interesting....

Signalling mechanisms involved in the induction of inducible nitric oxide synthase by Lactobacillus rhamnosus GG, endotoxin, and lipoteichoic acid.

BACKGROUND AND AIMS:
Probiotic Lactobacillus rhamnosus GG (Lactobacillus GG) has been found beneficial in the treatment of viral and antibiotic-associated diarrhea. Recently, it has also been shown to induce nitric oxide (NO) production, and have some other immunostimulatory effects. The aim of the present study was to investigate the mechanisms involved in the induction of inducible nitric oxide synthase (iNOS) and NO production by Lactobacillus GG.

METHODS AND RESULTS:
iNOS expression and NO production induced by Lactobacillus GG, lipopolysaccharide (LPS), and lipoteichoic acid (LTA) was abrogated by NOS inhibitors L-NMMA and 1400W, by a protein synthesis inhibitor cycloheximide, by a tyrosine kinase inhibitor genistein and by a NF-kappaB inhibitor pyrrolidinedithiocarbamate (PDTC) in J774 macrophages. Polymyxin B inhibited NO production induced by LPS, but did not inhibit Lactobacillus GG induced NO production. p42/44 MAP-kinase inhibitor PD98059, dexamethasone and cyclosporine A inhibited partially iNOS protein expression and NO formation in Lactobacillus GG, LPS and LTA treated cells. Ro 31-8220 (protein kinase C inhibitor) and SB203580 (p38 MAP-kinase inhibitor) had only a minor effect on NO production.

CONCLUSIONS:
Lactobacillus GG induced NO production through iNOS pathway and the mechanisms mediating that process were very similar with those involved in LPS and LTA induced NO synthesis.

 

[Seven7]

@JES ok so after I research this I am going to pass for now, might try later if I crash (I am too much in a good place to mess it up) but the idea is that arginine will replicate herpes viruses. Since I have been bottling hh6v for 4 years I am NOT going to do anything that will help replication, I take antivirals to suppress the replication. I tread for plp like us we are suppose to keep lysine ratio high (instead of arginine). Thank you for the help!!!

 

[TiredSam]

Took 2 before lunch on Wednesday, found it hard to be objective and was of course over-analysing every little thing all afternoon and evening, but I had a very good rest of the day, and was hopeful.

Took 2 before breakfast and 2 before lunch on Thursday. I was absolutely wiped out from mid-morning, dragging myself through the rest of the day.

One thing I've noticed is that after taking them I feel very foggy for a couple of hours after.

I've cut down to 1 this morning before breakfast. When 1 of them doesn't make me feel foggy I might slowly increase.
So I've had my 36 hours and unfortunately I'm not cured yet. Be interested to hear how others are getting on.

 

[cigana]

So I've had my 36 hours and unfortunately I'm not cured yet. Be interested to hear how others are getting on.

I've done 24 hours, no improvement or change to report...

 

[gregh286]

I thought this was very interesting....

I've had a few fecal analysis done. One at KDM but GG is not listed as a fecal bacteria?
If it.was that simple we.lack NO producing gut bacteria it would be great.
http://ausfp.com/nitric-oxide-deficiency/

I remember reading russian atheletes used this strain to improve performance and reduce lactic load.