Think i got this test done years ago but it doesn't say on the results anything about a group. I attached it if you want a look.
Didn't Dr Myhill interpret your "ATP Profiles" test results for you? I know she charges extra for the interpretation.
I don't know too much about this, but from what I can see in your "ATP Profiles" test results, I do not think you are in Group A2, the group that Dr Myhill says benefit from taking Krebs cycle substrates.
In their published studies, Myhill, Booth and McLaren-Howard found that ME/CFS patients divide into two main groups, depending on whether their oxidative phosphorylation (which converts ADP to ATP) in the mitochondria is running normally (=
Group A), or is partially blocked and running with reduced efficiency (=
Group B).
Then they further divide Group A into subgroups:
Group A1 if your TL IN is low or normal;
Group A2 if your TL IN is higher than normal. (TL IN is the efficiency of mitochondrial translocator protein at transporting ATP created in the mitochondria into the cell, where the energy of ATP is needed for cellular functioning).
You can read more about this in the
Myhill 2013 paper (do a search for "A2" in this paper). Here is what they say:
Group A1: ‘no HIs’ patients appear not to suffer from substrate deficiencies in the processes leading to ATP delivery, while those in Group A2: ‘HI TL IN’ have substrate deficiencies.
Note though that your group can change over time, especially as a result of treatment.
If you look on your "ATP Profiles" test results, you see that your "ADP to ATP Efficiency" (which is oxidative phosphorylation) is 50.7%, and the normal range is > 60%. So this means your oxidative phosphorylation is running with reduced efficiency, and I think (but am not sure) this means you are in Group B.
I am not sure about your TL IN, I am not sure whether it is higher than normal, or lower than normal. You need to have it higher than normal to be in Group A2.
But I think you are not in the Group A at all; due to your lowered "ADP to ATP Efficiency", I think you will be in Group B. In
Myhill 2013 they say that D-ribose is an especially important nutrient for Group B patients. I would think D-ribose would be particularly useful to take during PEM periods.
That's my best attempt at interpretation, but actually your "ATP Profiles" is the first time that I have seen an example of this test on this forum.
You can see how Dr Myhill herself interprets one of these "ATP Profiles" tests at timecode 22:58 in
her video.
Here is what they say about higher than normal (super-normal) values for TL IN in
Myhill 2012:
The super-normal values of TL IN for the ‘HI TL IN’ patients are most likely due to below normal ATP levels in the mitochondria due to shortage of substrate, either the well-known substrates of the Krebs cycle or those of the ETC, principally ADP and inorganic phosphate, Pi, but also the essential co-factors CoQ10, reduced Niacinamide (NADH) and Mg.