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Complete remission of VZV reactivation treated with valganciclovir

heapsreal

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Varicella zoster virus (VZV), a threat for hematopoietic stem cell transplantation (HSCT) recipients, is still one of the most common viral pathogens that affect these patients with a reported incidence ranging between 17% and 50% in the post transplantation period. Valganciclovir (V-GCV), a valine ester pro-drug of GCV orally administrable, has recently shown great activity against CMV infections, but there are no reports of its clinical efficacy against VZV. We here report a case history of a patient with positive serologic test for VZV, who underwent allogeneic HSCT and devel- oped an atypical varicella-like illness. First-line therapy with foscarnet had to be discontinued due rapid development of renal impairment (creatinine: 2.60 mg/dL, urea: 130.6 mg/dL) and therefore was switched to V-GCV. The renal impairment and skin lesions of the patient fully recovered after few days of therapy, even though the patient had com- plete lymphocyte depletion. This is the first case of a patient with chickenpox-like illness treated successfully with V-GCV.

http://onlinelibrary.wiley.com/stor...35&s=cbd859a40f40a408bff739fff964a75a3407f29b
 

heapsreal

iherb 10% discount code OPA989,
Messages
10,077
Location
australia (brisbane)
About 3 weeks back on valcyte now. Inklings its helping. The headaches especially on the side of the shingles has reduced and the weird rash on my leg i got at the time of the head shingles is almost gone. Usually it flares up and down by now??

Time will tell .