• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To register, simply click the Register button at the top right.

Cobalamin Resistance


Senior Member
I had b12 tested once along with homocysteine and methymalonic acid? Anyway the b12 was out of range high (1100) and the other values were good. I notice an increase in energy from b12 sometimes, sometimes not. My symptoms like orthostatic hypotension seem to resemble b12 deficiency but I don’t think I have anemia. My methionine on a nutri Eval was just at the top of the reference range like maybe it wasn’t concerting. Can anyone tell me what cobalamin mutation I might have?