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Chronic widespread musculoskeletal pain, fatigue, depression & disordered sleep in post-SARS syndrome (2002 outbreak) (Moldofsky/Patcai 2011)

Pyrrhus

Senior Member
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U.S., Earth
Article about the "Post-SARS Syndrome" after the first SARS coronavirus outbreak in 2002:

Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study (Moldofsky and Patcai, 2011)
https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-11-37
Excerpt:
Moldofsky and Patcai 2011 said:
Background
The long term adverse effects of Severe Acute Respiratory Syndrome (SARS), a viral disease, are poorly understood.

Methods
Sleep physiology, somatic and mood symptoms of 22 Toronto subjects, 21 of whom were healthcare workers, (19 females, 3 males, mean age 46.29 yrs.+/- 11.02) who remained unable to return to their former occupation (mean 19.8 months, range: 13 to 36 months following SARS) were compared to 7 healthy female subjects. Because of their clinical similarities to patients with fibromyalgia syndrome (FMS) these post-SARS subjects were similarly compared to 21 drug free female patients, (mean age 42.4 +/- 11.8 yrs.) who fulfilled criteria for fibromyalgia.

Results
Chronic post-SARS is characterized by persistent fatigue, diffuse myalgia, weakness, depression, and nonrestorative sleep with associated REM-related apneas/hypopneas, an elevated sleep EEG cyclical alternating pattern, and alpha EEG sleep anomaly. Post- SARS patients had symptoms of pre and post-sleep fatigue and post sleep sleepiness that were similar to the symptoms of patients with FMS, and similar to symptoms of patients with chronic fatigue syndrome. Both post-SARS and FMS groups had sleep instability as indicated by the high sleep EEG cyclical alternating pattern rate. The post-SARS group had a lower rating of the alpha EEG sleep anomaly as compared to the FMS patients. The post-SARS group also reported less pre-sleep and post-sleep musculoskeletal pain symptoms.

Conclusions
The clinical and sleep features of chronic post-SARS form a syndrome of chronic fatigue, pain, weakness, depression and sleep disturbance, which overlaps with the clinical and sleep features of FMS and chronic fatigue syndrome.
 

Pyrrhus

Senior Member
Messages
4,172
Location
U.S., Earth
Related discussion:

Mental morbidities and chronic fatigue in severe acute respiratory syndrome survivors: long-term follow-up. (Lam et al., 2009)
https://forums.phoenixrising.me/thr...rs-later-27-met-cdc-critera-for-me-cfs.79381/
Main points:
  • 233 SARS survivors from hospitals of a local region in Hong Kong were assessed by psychometric questionnaires and a semistructured clinical interview for the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) to determine the presence of "psychiatric" disorders and chronic fatigue problems.
  • 40% of SARS-CoV (2002 epidemic) survivors still report Chronic Fatigue after long term followup 4 years later.
  • 27% met CDC critera for ME/CFS.