Chronic widespread musculoskeletal pain, fatigue, depression & disordered sleep in post-SARS syndrome; a case-controlled study (Moldofsky/Patcai 2011)

Pyrrhus

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Article about the "Post-SARS Syndrome" after the first SARS coronavirus outbreak in 2002:

Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study (Moldofsky and Patcai, 2011)
https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-11-37
Excerpt:
Moldofsky and Patcai 2011 said:
Background
The long term adverse effects of Severe Acute Respiratory Syndrome (SARS), a viral disease, are poorly understood.

Methods
Sleep physiology, somatic and mood symptoms of 22 Toronto subjects, 21 of whom were healthcare workers, (19 females, 3 males, mean age 46.29 yrs.+/- 11.02) who remained unable to return to their former occupation (mean 19.8 months, range: 13 to 36 months following SARS) were compared to 7 healthy female subjects. Because of their clinical similarities to patients with fibromyalgia syndrome (FMS) these post-SARS subjects were similarly compared to 21 drug free female patients, (mean age 42.4 +/- 11.8 yrs.) who fulfilled criteria for fibromyalgia.

Results
Chronic post-SARS is characterized by persistent fatigue, diffuse myalgia, weakness, depression, and nonrestorative sleep with associated REM-related apneas/hypopneas, an elevated sleep EEG cyclical alternating pattern, and alpha EEG sleep anomaly. Post- SARS patients had symptoms of pre and post-sleep fatigue and post sleep sleepiness that were similar to the symptoms of patients with FMS, and similar to symptoms of patients with chronic fatigue syndrome. Both post-SARS and FMS groups had sleep instability as indicated by the high sleep EEG cyclical alternating pattern rate. The post-SARS group had a lower rating of the alpha EEG sleep anomaly as compared to the FMS patients. The post-SARS group also reported less pre-sleep and post-sleep musculoskeletal pain symptoms.

Conclusions
The clinical and sleep features of chronic post-SARS form a syndrome of chronic fatigue, pain, weakness, depression and sleep disturbance, which overlaps with the clinical and sleep features of FMS and chronic fatigue syndrome.
 

Pyrrhus

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Related discussion:

Mental morbidities and chronic fatigue in severe acute respiratory syndrome survivors: long-term follow-up. (Lam et al., 2009)
https://forums.phoenixrising.me/thr...rs-later-27-met-cdc-critera-for-me-cfs.79381/
Main points:
  • 233 SARS survivors from hospitals of a local region in Hong Kong were assessed by psychometric questionnaires and a semistructured clinical interview for the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) to determine the presence of "psychiatric" disorders and chronic fatigue problems.
  • 40% of SARS-CoV (2002 epidemic) survivors still report Chronic Fatigue after long term followup 4 years later.
  • 27% met CDC critera for ME/CFS.