SwanRonson
Senior Member
- Messages
- 300
- Location
- Alabama
I've been researching the newly approved Japanese drug for CIC called Elobixibat. It's an ileal bile acid transport (i.e. re-uptake) inhibitor. I dug into this a bit and found that people with Gilbert's syndrome, like myself, usually have reduced bile acid output because of the UGT1A1 polymorphism. This would mean that a re-uptake inhibitor would probably be a good therapy for Gilbert's co-morbid CIC. Bile Acids are one of the big factors in stool softness and colonic motility.
As a side-note, I've noticed many times over the years that milk causes constipation worsening in me very reliably. Nothing dries out my stool and stops things moving like milk does. It's the worst. And, I found a study showing that milk products precipitate secondary bile acids, which is bad when you already have low BA liver output. I'd love to drink more milk, but I guess that's out until Elobixibat comes to the U.S.
My mother also has had CIC her entire life, as did her mother. She also has GS.
Anyone else with Gilbert's Syndrome also have CIC?
As a side-note, I've noticed many times over the years that milk causes constipation worsening in me very reliably. Nothing dries out my stool and stops things moving like milk does. It's the worst. And, I found a study showing that milk products precipitate secondary bile acids, which is bad when you already have low BA liver output. I'd love to drink more milk, but I guess that's out until Elobixibat comes to the U.S.
My mother also has had CIC her entire life, as did her mother. She also has GS.
Anyone else with Gilbert's Syndrome also have CIC?