Chronic Fatigue Syndrome Research: Difference in Blood Levels of Vitamin E
Wednesday August 11, 2010
http://chronicfatigue.about.com/b/2...h-difference-in-blood-levels-of-vitamin-e.htm
Research Brief
New research out of Japan suggests that abnormal fluctuations in vitamin E levels are linked to symptom flares and remissions in chronic fatigue syndrome (ME/CFS).
Researchers looked at vitamin E levels in serum (a fluid that can be extracted from blood) and found that they're lower overall in people with ME/CFS than in healthy controls. They also discovered that vitamin E levels are higher in ME/CFS patients during remission than when symptoms are more severe.
Vitamin E is an antioxidant, and researchers concluded that the fluctuating levels may be evidence that ME/CFS is linked to oxidative stress, and that an individual's current level of oxidative stress may be directly linked to symptom severity.
These findings are in line with several previous studies, which have lead some doctors to recommend anti-oxidant supplements for ME/CFS patients.
http://www.ncbi.nlm.nih.gov/pubmed/20676841
Heart Vessels. 2010 Jul;25(4):319-23. Epub 2010 Jul 31.
Fluctuation of serum vitamin E (alpha-tocopherol) concentrations during exacerbation and remission phases in patients with chronic fatigue syndrome.
Miwa K, Fujita M.
Department of Internal Medicine, Nanto Family and Community Medical Center, 577 Matsubara, Nanto, Toyama 939-1518, Japan. k-3wa@pm.ctt.ne.jp
Abstract
The etiology of chronic fatigue syndrome remains unknown. Oxidative stress may be involved in its pathogenesis. Vitamin E is a major endogenous lipid-soluble antioxidative substance, and is consumed during the lipid peroxidation process. We studied a population comprising 27 patients with chronic fatigue syndrome (10 men and 17 women, 29 +/- 6 years of age) and 27 age- and sex-matched control subjects. Serum vitamin E (alpha-tocopherol) concentrations were determined and expressed as mg/g total lipids (total cholesterol and triglyceride) to evaluate oxidative stress. Serum alpha-tocopherol concentrations (mg/g lipids) were significantly (P < 0.001) lower in the patients with chronic fatigue syndrome (2.81 +/- 0.73) than in the control subjects (3.88 +/- 0.65). The patients with chronic fatigue syndrome were re-examined during a follow-up interval. After 8 +/- 2 months, 16 patients exhibited a status that warranted re-examination during remission of the symptoms at a regular visit to our hospital (Group 1), while the remaining 11 did not (Group 2). The serum alpha-tocopherol levels were significantly elevated during remission as compared with those at baseline in Group 1 (2.71 +/- 0.62 --> 3.24 +/- 0.83, P < 0.001). The levels did not significantly change after the interval in Group 2 (2.97 +/- 0.86 --> 2.85 +/- 0.73, not significant). In conclusion, serum alpha-tocopherol concentrations were significantly lower in the patients with chronic fatigue syndrome as compared with the control subjects, suggesting increased oxidative stress in the former. The low level of serum alpha-tocopherol was ameliorated during the remission phase as compared with the exacerbation phase in the patients with chronic fatigue syndrome, suggesting that increased oxidative stress may be involved in the pathogenesis of chronic fatigue syndrome and might also be directly related to the severity of the symptoms of chronic fatigue syndrome.
PMID: 20676841 [PubMed - in process]
Wednesday August 11, 2010
http://chronicfatigue.about.com/b/2...h-difference-in-blood-levels-of-vitamin-e.htm
Research Brief
New research out of Japan suggests that abnormal fluctuations in vitamin E levels are linked to symptom flares and remissions in chronic fatigue syndrome (ME/CFS).
Researchers looked at vitamin E levels in serum (a fluid that can be extracted from blood) and found that they're lower overall in people with ME/CFS than in healthy controls. They also discovered that vitamin E levels are higher in ME/CFS patients during remission than when symptoms are more severe.
Vitamin E is an antioxidant, and researchers concluded that the fluctuating levels may be evidence that ME/CFS is linked to oxidative stress, and that an individual's current level of oxidative stress may be directly linked to symptom severity.
These findings are in line with several previous studies, which have lead some doctors to recommend anti-oxidant supplements for ME/CFS patients.
http://www.ncbi.nlm.nih.gov/pubmed/20676841
Heart Vessels. 2010 Jul;25(4):319-23. Epub 2010 Jul 31.
Fluctuation of serum vitamin E (alpha-tocopherol) concentrations during exacerbation and remission phases in patients with chronic fatigue syndrome.
Miwa K, Fujita M.
Department of Internal Medicine, Nanto Family and Community Medical Center, 577 Matsubara, Nanto, Toyama 939-1518, Japan. k-3wa@pm.ctt.ne.jp
Abstract
The etiology of chronic fatigue syndrome remains unknown. Oxidative stress may be involved in its pathogenesis. Vitamin E is a major endogenous lipid-soluble antioxidative substance, and is consumed during the lipid peroxidation process. We studied a population comprising 27 patients with chronic fatigue syndrome (10 men and 17 women, 29 +/- 6 years of age) and 27 age- and sex-matched control subjects. Serum vitamin E (alpha-tocopherol) concentrations were determined and expressed as mg/g total lipids (total cholesterol and triglyceride) to evaluate oxidative stress. Serum alpha-tocopherol concentrations (mg/g lipids) were significantly (P < 0.001) lower in the patients with chronic fatigue syndrome (2.81 +/- 0.73) than in the control subjects (3.88 +/- 0.65). The patients with chronic fatigue syndrome were re-examined during a follow-up interval. After 8 +/- 2 months, 16 patients exhibited a status that warranted re-examination during remission of the symptoms at a regular visit to our hospital (Group 1), while the remaining 11 did not (Group 2). The serum alpha-tocopherol levels were significantly elevated during remission as compared with those at baseline in Group 1 (2.71 +/- 0.62 --> 3.24 +/- 0.83, P < 0.001). The levels did not significantly change after the interval in Group 2 (2.97 +/- 0.86 --> 2.85 +/- 0.73, not significant). In conclusion, serum alpha-tocopherol concentrations were significantly lower in the patients with chronic fatigue syndrome as compared with the control subjects, suggesting increased oxidative stress in the former. The low level of serum alpha-tocopherol was ameliorated during the remission phase as compared with the exacerbation phase in the patients with chronic fatigue syndrome, suggesting that increased oxidative stress may be involved in the pathogenesis of chronic fatigue syndrome and might also be directly related to the severity of the symptoms of chronic fatigue syndrome.
PMID: 20676841 [PubMed - in process]