From what I have heard, mitochondrial disease is generally thought to be there from birth, hence the roadblock to the idea it can happen later in life, i.e. ME CFS
What did come to mind is that maybe we too have some sort of genetic fault in our mitochondria and then the rest of the triggers set in and we wind up with CFIDS. Dr. Kerr did find 88 genes associated with CFIDS and one (or maybe more) of those genes was a downregulated Mitochondria gene. Hope I didn't mess this one up - so double check what I have noted here.