• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

CFS hormornal connection women

undcvr

Senior Member
Messages
822
Location
NYC
More women get CFS than men do and it seems harder for them to come out of it too. Can someone please share some of the theories out there about the hormornal connection?
 

halcyon

Senior Member
Messages
2,482
I seem to recall reading something about women suffering more of a shift to th2 dominance during monthly cycles. I can't seem to find any supporting evidence for this and of course the th1/th2 balance theory is highly simplified and may have no basis in reality.
 

Ema

Senior Member
Messages
4,729
Location
Midwest USA
A woman's immune system has to be more easily immunosuppressed in order to facilitate pregnancy. This could play a role. High progesterone levels are also known to be highly immunosuppressive (as in pregnancy).
 

PDXhausted

Senior Member
Messages
258
Location
NW US
Yes, to echo the others, progesterone is thought to suppress TH1 immunity-- or if that is an obsolete abstraction, it is immunosuppressive in some ways. Years of continuous oral contraceptives (ie daily exogenous estrogen and progesterone) have played a huge role in my disease process.

Estrogen can affect certain pathogens as well. The thing is, hormones play such a ubiquitous role in the body (how vitamins and minerals are used, immune system, interaction with microbiome, etc), there are many pathways in which they can affect a disease process. The problem with medical research is that it doesn't often control for this factor. Women have very dynamic systems.
 

undcvr

Senior Member
Messages
822
Location
NYC
Wud DIM or Indole 3 Carbon? help with this? It would seem like it is a steroid production thing and along the way it goes astray or goes into other systems? Say if you used a stating to take back the steroids that the pathogens are stealing intracellularly to make their viral coat?
 

heapsreal

iherb 10% discount code OPA989,
Messages
10,079
Location
australia (brisbane)
I think with chronic diseases there is an anabolic/catabolic imbalance going on. Good testosterone levels can help overcome this which is really a male dominated thing. If males are low in T the replacement dosages can help switch the balance to a more anabolic state which improves general recovery growth and repair.

I'm really not sure what the main anabolic hormone is in women? Maybe dhea and small doses of testosterone could help?

anything part of this theory is poor sleep as this drains growth hormone production, so good sleep can improve growth hormone secretion and improve the anabolic ratio.

protein intake plays a role here and to me it seems many women don't eat a lot of protein foods, which intake would need to be higher if in a catabolic state? ?
 

undcvr

Senior Member
Messages
822
Location
NYC
I was wondering if there are any women out there who have taken or who are on statins and if it indirectly helped their CFS/FM or Lyme
 

Ema

Senior Member
Messages
4,729
Location
Midwest USA
Didn't Teitelbaum have a treatment protocol involving statins?

I seem to remember something about how people on statins have pain similar to fibromyalgia due to lack of coQ10 as well.

Ah, yes. Here it is:

http://m.psychologytoday.com/blog/c...ng-new-discovery-in-treating-cfs-fibromyalgia

Wonder where this stands now?

It seems like if you already have the low cholesterol and pregnenolone (as I do), you could just skip the statins? I took coQ10 forever though and never noticed any changes.
 

undcvr

Senior Member
Messages
822
Location
NYC
Yes but that article also says that statins are highly antiviral and work like interferons. There are many analogues that work along the same pathway and do not have the statin side effects.
 

Ema

Senior Member
Messages
4,729
Location
Midwest USA
Yes but that article also says that statins are highly antiviral and work like interferons. There are many analogues that work along the same pathway and do not have the statin side effects.
So were you thinking that statins would improve symptoms by another pathway?
 

undcvr

Senior Member
Messages
822
Location
NYC
idk i was part of a trial that is a blend of plant waxes. They are trying to patent it, so i can't say too much about it. I am feeling the best that I have in all my life that i decided to stay on it even after the trial. From what I understand it is 'statin-like' but there are no side effects and it is non-toxic.