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CD1d Restriction and Th1/Th2/Th17 Cytokine


Senior Member
J Immunol. 2013 Jul 1;191(1):30-4. doi: 10.4049/jimmunol.1300121. Epub 2013 Jun 5.

Cutting edge:CD1d restriction and Th1/Th2/Th17 cytokine secretion by human Vδ3 Tcells.

Mangan BA, Dunne MR, O'Reilly VP, Dunne PJ, Exley MA, O'Shea D, Scotet E, Hogan AE, Doherty DG.

Source Department of Immunology, School of Medicine, Trinity College Dublin, Dublin 8, Ireland.


Human γδ T cells expressing the Vδ3 TCR make up a minor lymphocyte subset in blood but are enriched in liver and in patients with some chronic viral infections and leukemias. We analyzed the frequencies, phenotypes, restriction elements, and functions of fresh and expanded peripheral blood Vδ3 T cells. Vδ3 T cells accounted for ~0.2% of circulating T cells, included CD4(+), CD8(+), and CD4(-)CD8(-) subsets, and variably expressed CD56, CD161, HLA-DR, and NKG2D but neither NKG2A nor NKG2C. Vδ3 T cells were sorted and expanded by mitogen stimulation in the presence of IL-2. Expanded Vδ3 T cells recognized CD1d but not CD1a, CD1b, or CD1c. Upon activation, they killed CD1d(+) target cells, released Th1, Th2, and Th17 cytokines, and induced maturation of dendritic cells into APCs. Thus, Vδ3 T cells are glycolipid-reactive T cells with distinct Ag specificities but functional similarities to NKT cells.

Don't know the researchers, behind a paywall

γδ T Cells in Viral Disease
T cells are a functionally heterogeneous population and contribute to many early immune responses.

Alterations in peripheral blood γδ T cell subsets occur in individuals infected with a variety of viruses, including HIV (126), but more recent in vivo studies are further clarifying their role in viral infection. In early stages of both HIV infection (126) and human cytomegalovirus infection (127), expansion of the Vδ2-negative subset is observed and is associated with early protection (126). The γδ T cell subset Vδ1 also expands later in HIV infection and produces inflammatory cytokines (128), which suggests that both of the major human γδ T cell subsets respond to viral infection. In infants infected with respiratory syncytial virus (RSV), γδ T cells possess a diminished capacity for IFN-γ production. Children that developed subsequent recurrent wheezing had fewer IFN-γ-expressing γδ T cells than recovered children (129). These data suggest a possible protective role for γδ T cells during viral infection.



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