Can Methotrexate be used for ME?

[carvahlo]

I have just started taking Methotrexate for my eczema, I have just seen that there is some link to improving ME. So far I have taken one small dose and it has made me very tired, my energy levels have dipped a lot. Is there many studies to show it can help ME, because if the side effects continue and my energy levels don't pick up I am very unlikely to stay on this medication, unless it has a dramatic effect on my eczema

 

[Murph]

It supposedly caused remission in Fluge and Mella's very first patient.

There are a few threads here by people using it. There's not much buzz around it and I think positive results have been rare.

http://forums.phoenixrising.me/index.php?threads/methotrexate-my-feedback-on-use.51582/#post-852176
http://forums.phoenixrising.me/index.php?threads/methotrexate.36686/

 

[pattismith]

Methotrexate has inflammatory and immunosupressive functions.

It can improve ME or make it worse, so you will have to pay attention to your feelings.

 

[Marky90]

I know Fluge and Mella patented Methotrexate for ME, but seem to remember they stopped looking into it due to side effects in pilot patients. @deleder2k

 

[pattismith]

Warning, the risk for toxicity is increased for MTHFR C677T polymorphism (especially when homozygous).

For MTHFR A1298C polymorphism, the risk is not clearly modifyed