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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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I don't know. Are we at a stage yet where finding yet more "potential biomarkers" with little to no chance of leading to treatments is a low priority?
I've seen plenty of papers like this and I know they add to the great big pile of evidence for it being a physical condition but I fear they're not where you would invest if you were racing to find a cure? tell me I'm wrong.
I agree they are puzzle pieces.I do agree of course, but :
Biomarkers help in early diagnosis, disease prevention, drug target identification, drug response etc. (From the very scientific correct and trustworthy Wikipedia )
I wouldn't put my money in those kind of research either, but they all puts bits to the puzzle?
And maybe, in the long run, those small pieces helps to target the right kind of treatment?
I don't know. Are we at a stage yet where finding yet more "potential biomarkers" with little to no chance of leading to treatments is a low priority?
I've seen plenty of papers like this and I know they add to the great big pile of evidence for it being a physical condition but I fear they're not where you would invest if you were racing to find a cure? tell me I'm wrong.
I agree they are puzzle pieces.
But are they the corner pieces of the jigsaw that really help you get cracking!?
https://www.frontiersin.org/article...bmJ-Burzm_O2Sc1m1p_YUrFxGQ427rgbAM29e70yflSg4I don't know. Are we at a stage yet where finding yet more "potential biomarkers" with little to no chance of leading to treatments is a low priority?
I've seen plenty of papers like this and I know they add to the great big pile of evidence for it being a physical condition but I fear they're not where you would invest if you were racing to find a cure? tell me I'm wrong.
https://www.frontiersin.org/article...bmJ-Burzm_O2Sc1m1p_YUrFxGQ427rgbAM29e70yflSg4
@Murph
I thougt of you when i read the intro to this paper:
(I haven't read the actual article.)
Full paper now published by VanElzakker et al. The paper is a comprehensive review of ME/CFS neuroimaging studies.
"The ME/CFS research field has been stuck in a somewhat defensive posture, with a focus on demonstrating “this is a real condition” by showing significant biological differences between patients and controls. We believe this has led to a situation in which too much is made of the specifics reported by descriptive studies (such as the average “cytokine profile” present in cases vs. controls at the moment of assay) and not enough emphasis has been placed on potential mechanisms driving symptoms. The field is ready to move past proving “this is a real condition” and to start elucidating the specific relationship of ME/CFS symptoms to neuroinflammation."
Ha! Van Elzakker is a smart guy and now we know why - it looks like he's been reading my comments.