Blood volume

[Sizzle]

Is there any confirmation that low blood volume is the cause of POTS?
Or could it be that there is another explanation like endothelial inflammation?

 

[Learner1]

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6806054/

https://www.sciencedirect.com/science/article/pii/S0889159115300209

https://www.ahajournals.org/doi/10.1161/JAHA.119.013602

 

[Pyrrhus]

Is there any confirmation that low blood volume is the cause of POTS?

Low blood volume can make POTS worse, but it is not the cause of POTS.

The cause of POTS is dysautonomia.

The articles that @Learner1 shared suggest that autoimmunity may be behind this dysautonomia.

For more information, see:

Orthostatic Intolerance Basics: Dysautonomia of Blood Vessels, Low Blood Volume, and Baroreflexes
https://forums.phoenixrising.me/thr...sels-low-blood-volume-and-baroreflexes.86445/