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Hi there,
I wanted to share a couple of blog posts I wrote about ME/CFS, blood flow and how this might relate to the similarities between sepsis and ME/CFS.
The first one is about the type of blood flow you find in capillaries in sepsis. In sepsis, you have some capillaries with normal blood flow, while neighboring capillaries can have no blood flow or slow blood flow. This is a situation often called "heterogenous perfusion". This results in trouble extracting oxygen from the blood and making energy from it, a situation you find in sepsis and in ME/CFS.
The second one centers a material called glycocalyx that lines the interior of blood vessels all over the body. Glycocalyx is lost in sepsis and its loss results in heterogeneous perfusion. Interestingly, various causes of CFS like infection, injuries, surgeries, and psychological stress may also lead to loss of glycocalyx.
I wanted to share a couple of blog posts I wrote about ME/CFS, blood flow and how this might relate to the similarities between sepsis and ME/CFS.
The first one is about the type of blood flow you find in capillaries in sepsis. In sepsis, you have some capillaries with normal blood flow, while neighboring capillaries can have no blood flow or slow blood flow. This is a situation often called "heterogenous perfusion". This results in trouble extracting oxygen from the blood and making energy from it, a situation you find in sepsis and in ME/CFS.
The second one centers a material called glycocalyx that lines the interior of blood vessels all over the body. Glycocalyx is lost in sepsis and its loss results in heterogeneous perfusion. Interestingly, various causes of CFS like infection, injuries, surgeries, and psychological stress may also lead to loss of glycocalyx.
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