Prusty liked my reply to one of his tweets in which I mentioned Ilexgenin A inhibiting DRP1.
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Bhupesh Prusty: "we are on a perfect path for identifying potential transferable factors in ME/CFS blood that can cause mito dysfunction..." GoFundMe
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gregh286
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Raghav,
good work sir.
Wonder its possible to get dimethyltyrosine from tyrosine? The seemingly effective element in SS-31?
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-019-1627-9
https://www.nature.com/articles/s41598-018-34251-8
These effects are due to the dimethyltyrosine contained within SS-31, and are not exerted by other related peptides such as SS-20, which lack this structure20
Sorry if thats overly basic Q.
Ta.
good work sir.
Wonder its possible to get dimethyltyrosine from tyrosine? The seemingly effective element in SS-31?
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-019-1627-9
https://www.nature.com/articles/s41598-018-34251-8
These effects are due to the dimethyltyrosine contained within SS-31, and are not exerted by other related peptides such as SS-20, which lack this structure20
Sorry if thats overly basic Q.
Ta.
gregh286
Senior Member
- Messages
- 976
- Location
- Londonderry, Northern Ireland.
good read.
https://books.google.co.uk/books?id...#v=onepage&q=dimethyltyrosine make-up&f=false
PAGE 260-263
https://books.google.co.uk/books?id...#v=onepage&q=dimethyltyrosine make-up&f=false
PAGE 260-263
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MonkeyMan
Senior Member
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Fantastic news amidst all the gloom. This gives me hope. Thanks for sharing, sebaaa.
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In conclusion, HHV-6 reactivation in ME/CFS patients activates a multisystem, proinflammatory, cell danger response that protects against certain RNA and DNA virus infections, but comes at the cost of mitochondrial fragmentation and severely compromised energy metabolism.
The paper will be available for the public to view in a few days.
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MonkeyMan
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I think it's time for the OMF to break their silence and comment on Prusty's work, and to let us know if the treatment they're working on is related to this breakthrough.
@MonkeyMan hope so to. Otherwise it feels like some kind of weird offended ego that the millions they got didnt made more progress than one man in his laboratory. But lets just wait and dont jump to conclusions just yet.
For what its worth, seems like the last word about Drp1 isnt spoken yet. So back to ordering virus contaminated
tea from China.
tea from China.
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This is a really long shot, but if like Prusty says, our disease provides protection from some RNA/DNA virus (at the expense of everything else) I wonder if the "something in the blood" could provide protection from covid19. Because if there was even a hint that that can be true, it would instantaneously unlock unlimited funding for ME/CFS research, given how the entire world is scrambling to find a way to treat or contain covid19. I wrote on Prusty's twitter account, I'm curious to see if he has an answer.
MonkeyMan
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Wow. I am more and more impressed with Dr Prusty. Not only is he obviously a brilliant researcher who may have discovered what is at the root of ME/CFS, but he is generous and caring, and takes the time to respond to questions from patients. He is a gift to all of us in the community.
MonkeyMan
Senior Member
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Wow. Now THAT is what I call thinking outside the box! If this is true, it could be an instant game-changer, enduin.
I guess the question is, are there ME/CFS patients who have contracted the coronavirus? (I've had ME/CFS for 35 years, never get colds or the flu, and have no signs of coronavirus, for whatever it's worth).
paul80
Senior Member
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What does this mean? has he not already solved what's in the blood? (herpes)
@paul80 he doesnt. But he said this again and again. The things he has found out and know right now: mitochondrial fragmentation and fission. Followed by low energy production. When he used Cfs plasma. Even if herpes viruses are the cause, he still doesnt know how they force not infected cells into hibernation antiviral defense mode. He is on it right now, but it will still take some time. But the things we can do right now till this is solved, find and take things that can resolve the fragmentation. So a symptomatic therapy till we can get a causal treatment.
Mary
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I know a couple who have. I had been wondering the same thing, if ME/CFS would be protective against COVID-19, because of Prusty's video where he shows that our cells are too weak - lack the necessary nutrients - to support fast-growing viruses like the flu. Perhaps we may have subgroups of people with a natural immunity of sorts, too weak to support COVID-19. I don't have a clue, am just speculating. I don't know what if any relation COVID-19 has to the flu. I last caught the flu 20 years ago, in the early stages of ME/CFS.
I think the lack of energy in Cfs for fast growing viruses is sadly nothing to explore for any form of treatment for Flu or covid. If you get it, its to late to starve the body from energy bc that would most likely kill the patient. Preemptively bringing ppl in a Cfs like status doesnt sound compelling either. Its like saying a person without legs cant break a leg. I wouldnt take my legs of in fear of breaking them haha.
Rufous McKinney
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I think there are many compelling reasons to further investigate ME...and its association with other viruses and Covid, etc....but getting ME is NO CURE FOR- a troubling flu if you ask me. Its just a sort of- coincidence- that we have something which seems to ALSO reduce our vulnerability to new viruses.
paul80
Senior Member
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Ok good explanation, thanks.
Think i would prefer if possible he puts his time into finding something to resolve the fragmentation. That surely should take priority over finding a complete cure.
Has anybody tried Mebendazole for fatigue ? It increases oxphos and reduces ROS. But the side effects have to be weighed in. There is a thread on PR dating back to 2011 where people reported dramatic reversal of symptoms after 4 hours of taking it. A bird tweeted this info. 
But it can cause diarrhoea and elevated liver enzymes. Maybe a reduced dosage will help giving relief. I get Mebendazole in 100mg tablets in India. It is used as an anti helminthic for worms. Maybe if we take a quarter tablet it can help. Just guessing wildly.
https://forums.phoenixrising.me/thr...-has-helped-my-gut-a-bit-but-why.11327/page-2
But it can cause diarrhoea and elevated liver enzymes. Maybe a reduced dosage will help giving relief. I get Mebendazole in 100mg tablets in India. It is used as an anti helminthic for worms. Maybe if we take a quarter tablet it can help. Just guessing wildly. https://forums.phoenixrising.me/thr...-has-helped-my-gut-a-bit-but-why.11327/page-2