Bad effects from methylcobalamin

[Dizzy2016]

Hi, just wondering if anyone knows what could have happened or be happening because I'm desperate for my life back.

Nov 2021 I took methylcobalamin for 5 days 1000mcg sublingual- I did not know about methylation. I was perfectly fine and healthy before, only took it as I had a blood test and the Dr said I needed to up my b12 abit so I just bought the first one I saw. Silly me!

I developed extreme anxiety and jittery from it, insomnia, so I stopped.
2 weeks later I started with random welts and sporadic urticaria and skin sensitivities.
Never ever had any allergy issues prior.
The urticaria and welts lasted exactly 4 months from the last dose.
February 2022 I had blood tests that showed I was now extremely aneamic which I hadn't been prior. I became very light sensitive, anxious and started having panic attacks- I've been aneamic before and never felt like this.
March I started hemaplex - didn't realise the methylcobalamin and methylfolate in it and took it for almost a month on and off - it made me very irritable, angry and spaced out.
March 14th I had been outside gardening no issues - had my tea and then had a vertigo attack! Never had anything like it before in my life - that was also when the panic attacks really ramped up - 24mg of benzo did nothing.
The drs diagnosed me with me vestibular neuronitis over the phone. Anyway I deteriorated and ended up bed bound completely from April-June unable to walk straight, constant dizziness - I realise now this was high histamine - I was supplementing heme iron( very high in histamine).
Then the dr said I needed b12 in may so I took cyanocobalamin 1000mcg sublingual, it gave me energy but my histamine worse.
I Stopped everything at the end of August.
The end of September a dr said oh you need methylcobalamin again so I took it again! Big regret - for 5 days until the 7th October and that was it! Once again urticuria for 4 months and welts, now I've got dysautonomia really bad, fatigue, sensitivities, heat intolerance, not been out of the house properly for months. Can't drive. Spend 90% of my time in bed.
I dont know what went wrong. I have HMTA shows low copper etc
high histamine urine test, low stomach acid. I had not one health issues prior to this. Now I cant even walk to the end of my garden. I have constant dizziness, ataxia, whooshing in my right ear, falls, tremors, palpitations. Every symptom of b12 deficiency but levels went back to exactly what they've always been. Any help would be appreciated sorry about the long write up.

 

[Idie]

Hi, just wondering if anyone knows what could have happened or be happening because I'm desperate for my life back.

Nov 2021 I took methylcobalamin for 5 days 1000mcg sublingual- I did not know about methylation. I was perfectly fine and healthy before, only took it as I had a blood test and the Dr said I needed to up my b12 abit so I just bought the first one I saw. Silly me!

I developed extreme anxiety and jittery from it, insomnia, so I stopped.
2 weeks later I started with random welts and sporadic urticaria and skin sensitivities.
Never ever had any allergy issues prior.
The urticaria and welts lasted exactly 4 months from the last dose.
February 2022 I had blood tests that showed I was now extremely aneamic which I hadn't been prior. I became very light sensitive, anxious and started having panic attacks- I've been aneamic before and never felt like this.
March I started hemaplex - didn't realise the methylcobalamin and methylfolate in it and took it for almost a month on and off - it made me very irritable, angry and spaced out.
March 14th I had been outside gardening no issues - had my tea and then had a vertigo attack! Never had anything like it before in my life - that was also when the panic attacks really ramped up - 24mg of benzo did nothing.
The drs diagnosed me with me vestibular neuronitis over the phone. Anyway I deteriorated and ended up bed bound completely from April-June unable to walk straight, constant dizziness - I realise now this was high histamine - I was supplementing heme iron( very high in histamine).
Then the dr said I needed b12 in may so I took cyanocobalamin 1000mcg sublingual, it gave me energy but my histamine worse.
I Stopped everything at the end of August.
The end of September a dr said oh you need methylcobalamin again so I took it again! Big regret - for 5 days until the 7th October and that was it! Once again urticuria for 4 months and welts, now I've got dysautonomia really bad, fatigue, sensitivities, heat intolerance, not been out of the house properly for months. Can't drive. Spend 90% of my time in bed.
I dont know what went wrong. I have HMTA shows low copper etc
high histamine urine test, low stomach acid. I had not one health issues prior to this. Now I cant even walk to the end of my garden. I have constant dizziness, ataxia, whooshing in my right ear, falls, tremors, palpitations. Every symptom of b12 deficiency but levels went back to exactly what they've always been. Any help would be appreciated sorry about the long write up.

Hello

It appears you have a pretty significant B12 deficiency. Dizziness, ataxia, tremors, palpitations are all right in the bullseye of a long standing B12 problem. It is not surprising to me that you were bed bound——B12 deficiency can make you feel like rubbish with weakness, dizziness and overall miserable feeling. I had all of this—and it was me who figured it out, not the many physicians I consulted. Measuring your blood serum is a waste of money once you have been supplementing. Your blood level will be high in B12 BUT that is not a good measurement——B12 in the tissues is what matters. Taking a little B12 will not fix the problem, you will have to be more aggressive in taking B12. It is also true that you often feel worse before you get better. I know that that is counterintuitive but it is extremely common. For me, it took 6 weeks before I saw improvement. Unfortunately, once you have a B12 deficiency, you will likely have it for life. What questions do you have that I can help answer?

 

[Dizzy2016]

Hello

It appears you have a pretty significant B12 deficiency. Dizziness, ataxia, tremors, palpitations are all right in the bullseye of a long standing B12 problem. It is not surprising to me that you were bed bound——B12 deficiency can make you feel like rubbish with weakness, dizziness and overall miserable feeling. I had all of this—and it was me who figured it out, not the many physicians I consulted. Measuring your blood serum is a waste of money once you have been supplementing. Your blood level will be high in B12 BUT that is not a good measurement——B12 in the tissues is what matters. Taking a little B12 will not fix the problem, you will have to be more aggressive in taking B12. It is also true that you often feel worse before you get better. I know that that is counterintuitive but it is extremely common. For me, it took 6 weeks before I saw improvement. Unfortunately, once you have a B12 deficiency, you will likely have it for life. What questions do you have that I can help answer?

Hi, I didnt have any b12 deficiency symptoms until I took methylcobalamin tho? I'm still bed bound and getting worse, but I can't take b12 as I have high histamine and it makes it worse.
I dont have high levels of b12 mine is always 200 its been 60 before and never had symptoms it's all very strange

 

[Idie]

Hi, I didnt have any b12 deficiency symptoms until I took methylcobalamin tho? I'm still bed bound and getting worse, but I can't take b12 as I have high histamine and it makes it worse.
I dont have high levels of b12 mine is always 200 its been 60 before and never had symptoms it's all very strange

Hello,

Yes, it seems counterintuitive BUT you can have symptoms that you do not feel and when you take B12 they begin to show themselves (this is why they call B12 deficiency so insidious). I had so many symptoms that showed up once I began B12. It is very scary to think that there is damage being done and you are unaware of it until the deficiency is quite advanced. Your levels are very low. I personally use Methylcobalamin because I believe it does the best job of ”fixing” all the damage. I tried Cynacobalamin and for me Methyl was far superior. There is a great deal of misinformation out there on B12 deficiency. I started using Methylcobalamin when it was relatively new. More and more people are beginning to see the benefits of this form. There is a forum on this site called B12—-you might find it helpful

 

[linusbert]

had my tea and then had a vertigo attack!

i did overread this at first.
what kind of tea do you drink? black tea? green tea?

some teas are known to bind and destroy thiamin in your guts.
so if you drink those, and i believe those are black and green teas, and if you drink those a lot... you can get thiamine deficiency.
i drank liter of green/white tea a day, it was a habbit... maybe this attributed to my decline.

also, some teas like earl grey have bergamot inside. bergamot blocks the potassium channels. people who are sensitive to this, can get muscle cramps and other things. i do.


also if you fear the supplements, try to eat liver like 50-100g max. per week.

or what i suggest for everyone are like 4-6 whole eggs with RUNNY egg yolk or just the yolk. this is very important for healing.


in general, if you hadnt tried the carnivore diet, i might suggest you have a look into this one. many casual reports popped out over the recent years where people healed completely just with that.
the most prominent is the peterson family.


also as i said in the other thread. i also do not believe b12 did make you sick, but you actually were before in a borderline deficient state.

this is a theory of mine:
if your body is deficient, it slows down metabolic processes or uses other processes. usually all vitamins go down at the same time. but they can even appear normal in blood, because your metabolism changed. slowed down. now your blood levels of nutrition reflect that what works for the current state ou are in. imagine you are 50% of normal.. than the body needs much less vitamins and co. you also might feel normal for a while.. maybe its a bit more sleepyness.. maybe just cold hands etc. nothing to much annoying.
but when you start to unblock your body with for example methylcobalamin or vitamin D.. your body gets up from 50% to maybe 80% in metabolism.. but now your vitamin stores are not sufficient enough anymore. now you are in a severe deficient state despite beeing "normal" in blood before.
the goal in that case would be to slowly ramp up , from like 50% .. to 55%.

 

[Dizzy2016]

i did overread this at first.
what kind of tea do you drink? black tea? green tea?

some teas are known to bind and destroy thiamin in your guts.
so if you drink those, and i believe those are black and green teas, and if you drink those a lot... you can get thiamine deficiency.
i drank liter of green/white tea a day, it was a habbit... maybe this attributed to my decline.

also, some teas like earl grey have bergamot inside. bergamot blocks the potassium channels. people who are sensitive to this, can get muscle cramps and other things. i do.


also if you fear the supplements, try to eat liver like 50-100g max. per week.

or what i suggest for everyone are like 4-6 whole eggs with RUNNY egg yolk or just the yolk. this is very important for healing.


in general, if you hadnt tried the carnivore diet, i might suggest you have a look into this one. many casual reports popped out over the recent years where people healed completely just with that.
the most prominent is the peterson family.


also as i said in the other thread. i also do not believe b12 did make you sick, but you actually were before in a borderline deficient state.

this is a theory of mine:
if your body is deficient, it slows down metabolic processes or uses other processes. usually all vitamins go down at the same time. but they can even appear normal in blood, because your metabolism changed. slowed down. now your blood levels of nutrition reflect that what works for the current state ou are in. imagine you are 50% of normal.. than the body needs much less vitamins and co. you also might feel normal for a while.. maybe its a bit more sleepyness.. maybe just cold hands etc. nothing to much annoying.
but when you start to unblock your body with for example methylcobalamin or vitamin D.. your body gets up from 50% to maybe 80% in metabolism.. but now your vitamin stores are not sufficient enough anymore. now you are in a severe deficient state despite beeing "normal" in blood before.
the goal in that case would be to slowly ramp up , from like 50% .. to 55%.

I drink black tea but with milk, I've read about with b1 especially.

So when one takes vitamin b12 methylcobalamin it puts everything else to use?? I dont understand why I got sporadic urticuria for exactly 4months after??

 

[Dizzy2016]

i did overread this at first.
what kind of tea do you drink? black tea? green tea?

some teas are known to bind and destroy thiamin in your guts.
so if you drink those, and i believe those are black and green teas, and if you drink those a lot... you can get thiamine deficiency.
i drank liter of green/white tea a day, it was a habbit... maybe this attributed to my decline.

also, some teas like earl grey have bergamot inside. bergamot blocks the potassium channels. people who are sensitive to this, can get muscle cramps and other things. i do.


also if you fear the supplements, try to eat liver like 50-100g max. per week.

or what i suggest for everyone are like 4-6 whole eggs with RUNNY egg yolk or just the yolk. this is very important for healing.


in general, if you hadnt tried the carnivore diet, i might suggest you have a look into this one. many casual reports popped out over the recent years where people healed completely just with that.
the most prominent is the peterson family.


also as i said in the other thread. i also do not believe b12 did make you sick, but you actually were before in a borderline deficient state.

this is a theory of mine:
if your body is deficient, it slows down metabolic processes or uses other processes. usually all vitamins go down at the same time. but they can even appear normal in blood, because your metabolism changed. slowed down. now your blood levels of nutrition reflect that what works for the current state ou are in. imagine you are 50% of normal.. than the body needs much less vitamins and co. you also might feel normal for a while.. maybe its a bit more sleepyness.. maybe just cold hands etc. nothing to much annoying.
but when you start to unblock your body with for example methylcobalamin or vitamin D.. your body gets up from 50% to maybe 80% in metabolism.. but now your vitamin stores are not sufficient enough anymore. now you are in a severe deficient state despite beeing "normal" in blood before.
the goal in that case would be to slowly ramp up , from like 50% .. to 55%.

If I am undermethylating that will be blocking my bodies access to its own methylb12 which I feel is happening but I don't know how to get the access back

 

[linusbert]

idk if undermethylation does block . i am no methylation expert btw.
a methylation trap can do this. and this is a complicated topic.

 

[Dizzy2016]

Probably a methylation block then

 

[linusbert]

Probably a methylation block then

maybe this helps https://me-pedia.org/wiki/Methylation_cycle_hypothesis

 

[Dizzy2016]

maybe this helps https://me-pedia.org/wiki/Methylation_cycle_hypothesis

I've got all this data I just can't work out what's blocked and how to unblock it

 

[Dizzy2016]

maybe this helps https://me-pedia.org/wiki/Methylation_cycle_hypothesis

Do you think glutathione would help?? I'm taking creatine

 

[Seadragon]

Hi, just wondering if anyone knows what could have happened or be happening because I'm desperate for my life back.

Nov 2021 I took methylcobalamin for 5 days 1000mcg sublingual- I did not know about methylation. I was perfectly fine and healthy before, only took it as I had a blood test and the Dr said I needed to up my b12 abit so I just bought the first one I saw. Silly me!

I developed extreme anxiety and jittery from it, insomnia, so I stopped.
2 weeks later I started with random welts and sporadic urticaria and skin sensitivities.
Never ever had any allergy issues prior.
The urticaria and welts lasted exactly 4 months from the last dose.
February 2022 I had blood tests that showed I was now extremely aneamic which I hadn't been prior. I became very light sensitive, anxious and started having panic attacks- I've been aneamic before and never felt like this.
March I started hemaplex - didn't realise the methylcobalamin and methylfolate in it and took it for almost a month on and off - it made me very irritable, angry and spaced out.
March 14th I had been outside gardening no issues - had my tea and then had a vertigo attack! Never had anything like it before in my life - that was also when the panic attacks really ramped up - 24mg of benzo did nothing.
The drs diagnosed me with me vestibular neuronitis over the phone. Anyway I deteriorated and ended up bed bound completely from April-June unable to walk straight, constant dizziness - I realise now this was high histamine - I was supplementing heme iron( very high in histamine).
Then the dr said I needed b12 in may so I took cyanocobalamin 1000mcg sublingual, it gave me energy but my histamine worse.
I Stopped everything at the end of August.
The end of September a dr said oh you need methylcobalamin again so I took it again! Big regret - for 5 days until the 7th October and that was it! Once again urticuria for 4 months and welts, now I've got dysautonomia really bad, fatigue, sensitivities, heat intolerance, not been out of the house properly for months. Can't drive. Spend 90% of my time in bed.
I dont know what went wrong. I have HMTA shows low copper etc
high histamine urine test, low stomach acid. I had not one health issues prior to this. Now I cant even walk to the end of my garden. I have constant dizziness, ataxia, whooshing in my right ear, falls, tremors, palpitations. Every symptom of b12 deficiency but levels went back to exactly what they've always been. Any help would be appreciated sorry about the long write up.

I get anxiety/jitteriness on any B vitamins and avoid them now.

Do you have a trusted doctor you can explain everything to and get medical advice for your Anaemia.

It sounds like you shouldn't be trying again on your own with your history of such severe reactions.

 

[TinaT]

I can't take b12 as I have high histamine and it makes it worse.
I dont have high levels of b12 mine is always 200 its been 60 before and never had symptoms it's all very strange

I think you should read the book "Could it be B12?"

I'm not an expert by any means. I can just tell you, from reading only parts of that book, you are severely deficient and, unfortunately, must somehow increase B12. The book says really you must have injections.

I know it's extremely difficult. I'm going through it right now. My problems aren't the same but they are ruining everything in my life.

"They" say it gets worse before it gets better. My big question has been how much worse. I know you said you will never take methyl again. Maybe try hydroxy?

 

[Dizzy2016]

I have a methyl block apparently so my body can't access its own methylb12
I tried hydroxo but no matter how much b12 I have my body can't handle any more as it has no where to go

 

[Dizzy2016]

I get anxiety/jitteriness on any B vitamins and avoid them now.

Do you have a trusted doctor you can explain everything to and get medical advice for your Anaemia.

It sounds like you shouldn't be trying again on your own with your history of such severe reactions.

I wish I'd never taken it, its ruined my life

 

[Jadzhia]

I'm going to suggest something based on what Dr Greg Russell-Jones (B12 biochemist guy) would say: you are clearly B2 deficient and that's why your body can't handle B12. You cannot expect to fix your B12 deficiency (which you clearly have) until you are replete in B2. So you'd need to start on taking a (very small given your history) amount of B2 (riboflavin) and see how you get on with that. Don't take any more B12!

 

[Dizzy2016]

I've not taken any more b12 and hope to never again not of any type its really ruined my life. Which b2 active or non active??

 

[Jadzhia]

I've not taken any more b12 and hope to never again not of any type its really ruined my life. Which b2 active or non active??

Plain ol' riboflavin. Not the R-5-P one.

 

[Dizzy2016]

OK thank you how much about 5mg?