Baclofen, an anti-inflammatory?

[Thinktank]

I sometimes use a low dose baclofen as a mild anxiolytic, usually before bed.
I've noticed that my skin and eyes looks much brighter the next morning. It feels like baclofen has some kind of anti-inflammatory effect on me.

Does anyone know if baclofen does in fact possess anti-inflammatory properties?

 

[Hd-x]

https://www.ncbi.nlm.nih.gov/pubmed/20201957

 

[frozenborderline]

following... jay goldstein used high dose baclofen as treamtnet

 

[Thinktank]

I've been dealing with high inflammation in my skin for a few weeks now, the inflammation is also making me very brain fogged.
Last night i took 5mg baclofen to hopefully improve the inflammation and as suspected it did. My facial skin looked calm when i woke up this morning, no more redness, My intestines hurt less and my brain fog has lifted some.

The article posted above mentions a reduction of chemokines after injection with baclofen in mice.

The anti-inflammatory effect of baclofen is truly profound, so if anyone else might have some clues on the how and why then please share.

 

[Thinktank]

I just skimmed through another paper discussing the anti-inflammatory effects of baclofen. If i understand it correctly it reduces the inflammatory signaling in glial cells.

I'm wondering if Jared Younger's list of anti-inflammatoy herbs might help me. His work is on microglial inflammation right?

 

[pattismith]

I've been dealing with high inflammation in my skin for a few weeks now, the inflammation is also making me very brain fogged.
Last night i took 5mg baclofen to hopefully improve the inflammation and as suspected it did. My facial skin looked calm when i woke up this morning, no more redness, My intestines hurt less and my brain fog has lifted some.

The article posted above mentions a reduction of chemokines after injection with baclofen in mice.

The anti-inflammatory effect of baclofen is truly profound, so if anyone else might have some clues on the how and why then please share.

I just skimmed through another paper discussing the anti-inflammatory effects of baclofen. If i understand it correctly it reduces the inflammatory signaling in glial cells.

I'm wondering if Jared Younger's list of anti-inflammatoy herbs might help me. His work is on microglial inflammation right?

https://forums.phoenixrising.me/threads/low-dose-naltrexone-for-charcot-neuropathy.84310/

Interesting that recent study found that association between low dose Baclofen + LDN + sorbitol reverse the course of CMT1A a severe neuropathic disease. As both baclofen and LDN are fibro/me drugs, combining them might be a good idea

 

[Insomniac]

Baclofen makes sleep quality better. Maybe that is why you wake up feeling better.

I wish I could take Baclofen everyday but I am very scared of tolerance and addiction. I remember reading in the Benzo forum of someone who was trying to stop Baclofen and their withdrawal symptoms sounded like hell.

 

[Thinktank]

Baclofen withdrawal can be brutal but it's nothing compared to benzodiazepine withdrawal.
I still use baclofen only occasionally, if i overdo it my myoclonus starts to act up and i become much more sensitive to sound (hyperacusis). Years of benzodiazepine usage has affected my nervous system severely.