Hi everybody,
somewhere in a post (I think by @Pyrrhus) I read that measuring virus titers is unreliable if IgM/IgG/IgA are low.
I wonder if the same applies to low B cells, specifically CD19+ and CD20+ B cells (CD20+ are depleted during Rituximab treatment if I understood correctly, and that suppresses autoimmune activity) with respect to autoimmunity markers. I don't know which antobodies CD19/CD20 produce, but I wondered if
1) there can be autoimmunity but it won't show in lab tests if CD19/CD20 are low,
or
2) having low CD19/CD20 "protects" against (at least certain forms of) autoimmunity, so having low CD19/CD20 can't lead to at least these forms of autoimmunity.
I have low/lowish CD19 and CD20 B cells, but I have Hashimoto's. In the Celltrend panel, two antibodies were positive, so there is some form of autoimmunity, but - as far as I can see it - not really severe. I wondered if autoimmunity lab tests are reliable if B cells are low. Does anybody know?
Thank you!
somewhere in a post (I think by @Pyrrhus) I read that measuring virus titers is unreliable if IgM/IgG/IgA are low.
I wonder if the same applies to low B cells, specifically CD19+ and CD20+ B cells (CD20+ are depleted during Rituximab treatment if I understood correctly, and that suppresses autoimmune activity) with respect to autoimmunity markers. I don't know which antobodies CD19/CD20 produce, but I wondered if
1) there can be autoimmunity but it won't show in lab tests if CD19/CD20 are low,
or
2) having low CD19/CD20 "protects" against (at least certain forms of) autoimmunity, so having low CD19/CD20 can't lead to at least these forms of autoimmunity.
I have low/lowish CD19 and CD20 B cells, but I have Hashimoto's. In the Celltrend panel, two antibodies were positive, so there is some form of autoimmunity, but - as far as I can see it - not really severe. I wondered if autoimmunity lab tests are reliable if B cells are low. Does anybody know?
Thank you!