@Pyrrhus - thanks for this thread. I imagine there are various stories scattered through the forum over the years. It's such a fine line in terms of discouragement and encouragement, but so many are already gone - the famous ME Day founder was someone who took his own life and I am quite sure he would be happy to know that someone is gathering these threads together. The issue of case definition and the IOM criteria was so hotly debated and what came of it? The Canadian Criteria was what people wanted to remain for research rather than spend the paltry $1 million USD on yet another criteria. But the situation is as yet so dire, I think those who participated in the IOM criteria just wanted something as proof. It's all about money - it's always money.