Association of Sinonasal Inflammation With Functional Brain Connectivity | Neurology | JAMA Otolaryngology–Head & Neck Surgery | JAMA Network
Conclusions and Relevance
In this case-control study, participants with sinonasal inflammation showed decreased brain connectivity within a major functional hub with a central role in modulating cognition.
This region also shows increased connectivity to areas that are activated during introspective and self-referential processing and decreased connectivity to areas involved in detection and response to stimuli.
Future prospective studies are warranted to determine the applicability of these findings to a clinical chronic rhinosinusitis population.