asperosaponin VI suppresses microglia activation and IDO activity

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Our results propose a promising antidepressant effect for ASA VI possibly through the downregulation of IDO expression and normalization of the aberrant glutamate transmission. This remedying effect of ASA VI could be attributed to suppress microglia-mediated neuroinflammatory response via inhibiting the TLR4/NF-κB signaling pathway.”

https://link.springer.com/article/10.1007/s00213-020-05553-5

The question is if microglia activation in ME is driven by TLR or for example TGFb