The decision to take the HAART is best left up to those who suffer. Remember, everyone on these drugs are monitored quite frequently for any problems. Tell the thousands or maybe the millions who take LDN that it doesn't work and they would laugh at you. The reason that there aren't a large number of studies about LDN for various diseases is that usually the drug companies pays the bill for them. And no drug company in their right mind is going to spend the huge sums of money necessary to do so for a generic drug, which the patent has long since expired and they will not get rich on. Remember, LDN is about $23.00 per month plus a small fee for shipping. Let's do the math here, if I were a drug company which drug would I promote, a $23.00 drug or a $1,400 drug? It's a no-brainer!
For those who would like to know how actual users of LDN feel, join the LDN Support Group at Yahoo and get your information, straight from the horses, or the patients mouths!
The decision whether to prescribe a drug is best left to doctors who are trained to make complex decisions.If anyone chooses to take a drug combination that could destroy already damaged mitochondria then they deserve facts and not speculation
As for LDN
The only published data on the use of low-dose naltrexone has been in Crohn's disease and irritable bowel syndrome.
These were both open-label pilot studies.
The fact that it is open label indicates that there was no placebo group to compare to, making it impossible to differentiate the effects from a placebo effect.
Also, as in all pilot studies the purpose of these studies is to design a future clinical study and not enough patients are included to be able to determine whether a result is statistically significant (as the range of responses needs to be determined first by a previous pilot study.
It is unlikely that opioid blockade with naltrexone has any effect on the immune system, as none has been demonstrated in the scientific literature in vivo or in live patients.
The proposed mechanisms of LDN on the immune system are self contradictory indicating that it is immunomodulatory when no such evidence exists.
Opioids are immunosuppressive and there is no known effect of lose dose blockade of opioids, nor is there any evidence in the literature that low dose blockade with LDN results in a release of opioids at some later time, not just at a therapeutic dose but also not at any detectable dose at all.
As LDN is a psychotropic drug i,m not suprised that people feel better but there is no objective benefit on any symptom caused by the disease of ME.
No amount of laughter can change that fact
There are a number of ongoing studies on LDN.Pharmaceutical companies can only promote liscensed drugs. To get a liscence there must be evidence of efficacy and safety.LDN has neither--that is the no brainer part
There have in fact allready been a large number of studies looking at the effectiveness of LDN all negative another no brainer